{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Amat-Bou M"],"funding":["Barcelona Magic Line"],"pagination":["E3123"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7650793"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(10)"],"pubmed_abstract":["Prader-Willi syndrome (PWS) is a rare genetic disorder characterized by a wide range of clinical manifestations, including obesity, hyperphagia, and behavioral problems. <i>Bifidobacterium animalis</i> subsp. <i>lactis</i> strain BPL1 has been shown to improve central adiposity in adults with simple obesity. To evaluate BPL1's effects in children with PWS, we performed a randomized crossover trial among 39 patients (mean age 10.4 years). Participants were randomized to placebo-BPL1 (<i>n</i> = 19) or BPL1-placebo (<i>n</i> = 20) sequences and underwent a 12-week period with placebo/BPL1 treatments, a 12-week washout period, and a 12-week period with the crossover treatment. Thirty-five subjects completed the study. The main outcome was changes in adiposity, measured by dual-energy X-ray ab"],"journal":["Nutrients"],"pubmed_title":["Effects of <i>Bifidobacterium animalis</i> Subsp. <i>lactis</i> (BPL1) Supplementation in Children and Adolescents with Prader-Willi Syndrome: A Randomized Crossover Trial."],"pmcid":["PMC7650793"],"funding_grant_id":["n.a."],"pubmed_authors":["Garcia-Ribera S","Sanchez-Infantes D","Ramon-Krauel M","Amat-Bou M","Lerin C","Piquer-Garcia I","Elias M","Corripio R","Ramon D","Climent E","Jimenez-Chillaron JC","Chenoll E","Ibanez L","Villalta L"],"additional_accession":[]},"is_claimable":false,"name":"Effects of <i>Bifidobacterium animalis</i> Subsp. <i>lactis</i> (BPL1) Supplementation in Children and Adolescents with Prader-Willi Syndrome: A Randomized Crossover Trial.","description":"Prader-Willi syndrome (PWS) is a rare genetic disorder characterized by a wide range of clinical manifestations, including obesity, hyperphagia, and behavioral problems. <i>Bifidobacterium animalis</i> subsp. <i>lactis</i> strain BPL1 has been shown to improve central adiposity in adults with simple obesity. To evaluate BPL1's effects in children with PWS, we performed a randomized crossover trial among 39 patients (mean age 10.4 years). Participants were randomized to placebo-BPL1 (<i>n</i> = 19) or BPL1-placebo (<i>n</i> = 20) sequences and underwent a 12-week period with placebo/BPL1 treatments, a 12-week washout period, and a 12-week period with the crossover treatment. Thirty-five subjects completed the study. The main outcome was changes in adiposity, measured by dual-energy X-ray ab","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Oct","modification":"2026-04-07T17:42:55.104Z","creation":"2020-11-19T16:56:59Z"},"accession":"S-EPMC7650793","cross_references":{"pubmed":["33066107"],"doi":["10.3390/nu12103123"]}}