biostudies-literatureUnknown40(6)Erukainure OLThe World Academy of SciencesThe global spread of the coronavirus infections disease - 2019 (COVID-19) and the search for new drugs from natural products particularly from plants are receiving much attention recently. In this study, the therapeutic potential of a new iridoid glycoside isolated from the leaves of <i>Clerodendrum volubile</i> against COVID-19 was investigated. Harpagide 5-O-β-D-glucopyranoside (HG) was isolated, characterised and investigated for its druglikeness, optimized geometry, and pharmacokinetics properties. Its immunomodulatory was determined by chemiluminescence assay using polymorphonuclear neutrophils (PMNs) in addition to T-cell proliferation assay. <i>In silico</i> analysis was used in determining its molecular interaction with severe acute respiratory syndrome coronavirus-2 (SARS-COV-2). Journal of biomolecular structure & dynamics2475-2488https://www.ebi.ac.uk/biostudies/studies/S-EPMC7651195biostudies-literatureTargeting the initiation and termination codons of SARS-CoV-2 spike protein as possible therapy against COVID-19: the role of novel harpagide 5-O-β-D-glucopyranoside from <i>Clerodendrum volubile</i> P Beauv. (Labiatae).PMC7651195Ebhuoma OOIbeji CUMuhammad AAtolani OKatsayal SBMesaik MAErukainure OLfalseTargeting the initiation and termination codons of SARS-CoV-2 spike protein as possible therapy against COVID-19: the role of novel harpagide 5-O-β-D-glucopyranoside from <i>Clerodendrum volubile</i> P Beauv. (Labiatae).The global spread of the coronavirus infections disease - 2019 (COVID-19) and the search for new drugs from natural products particularly from plants are receiving much attention recently. In this study, the therapeutic potential of a new iridoid glycoside isolated from the leaves of <i>Clerodendrum volubile</i> against COVID-19 was investigated. Harpagide 5-O-β-D-glucopyranoside (HG) was isolated, characterised and investigated for its druglikeness, optimized geometry, and pharmacokinetics properties. Its immunomodulatory was determined by chemiluminescence assay using polymorphonuclear neutrophils (PMNs) in addition to T-cell proliferation assay. <i>In silico</i> analysis was used in determining its molecular interaction with severe acute respiratory syndrome coronavirus-2 (SARS-COV-2). 2022-01-01T00:00:00Z2022 Apr2026-05-08T13:36:55.132Z2020-11-19T13:40:25ZS-EPMC76511953314070610.1080/07391102.2020.1840439