{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Doyle SR"],"funding":["RCUK | Biotechnology and Biological Sciences Research Council","Wellcome Trust","Biotechnology and Biological Sciences Research Council"],"pagination":["656"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7652881"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["3(1)"],"pubmed_abstract":["Haemonchus contortus is a globally distributed and economically important gastrointestinal pathogen of small ruminants and has become a key nematode model for studying anthelmintic resistance and other parasite-specific traits among a wider group of parasites including major human pathogens. Here, we report using PacBio long-read and OpGen and 10X Genomics long-molecule methods to generate a highly contiguous 283.4 Mbp chromosome-scale genome assembly including a resolved sex chromosome for the MHco3(ISE).N1 isolate. We show a remarkable pattern of conservation of chromosome content with Caenorhabditis elegans, but almost no conservation of gene order. Short and long-read transcriptome sequencing allowed us to define coordinated transcriptional regulation throughout the parasite's life cyc"],"journal":["Communications biology"],"pubmed_title":["Genomic and transcriptomic variation defines the chromosome-scale assembly of Haemonchus contortus, a model gastrointestinal worm."],"pmcid":["PMC7652881"],"funding_grant_id":["WT206194","BB/M003949/1","BB/K020048/1","BB/P024610/1","067811"],"pubmed_authors":["Bazant W","Sargison N","Rodgers FH","Noonan JD","Quail MA","Tracey A","Holroyd N","Laing R","Beasley H","Sankaranarayanan G","Doyle SR","Howe KL","Beech R","Salle G","Bartley D","Cotton JA","Wit J","Britton C","Devaney E","Chaudhry U","Paulini M","Gilleard JS","Redman E","Brooks K","Shabbir MZ","Martinelli A","Berriman M","Maitland K"],"additional_accession":[]},"is_claimable":false,"name":"Genomic and transcriptomic variation defines the chromosome-scale assembly of Haemonchus contortus, a model gastrointestinal worm.","description":"Haemonchus contortus is a globally distributed and economically important gastrointestinal pathogen of small ruminants and has become a key nematode model for studying anthelmintic resistance and other parasite-specific traits among a wider group of parasites including major human pathogens. Here, we report using PacBio long-read and OpGen and 10X Genomics long-molecule methods to generate a highly contiguous 283.4 Mbp chromosome-scale genome assembly including a resolved sex chromosome for the MHco3(ISE).N1 isolate. We show a remarkable pattern of conservation of chromosome content with Caenorhabditis elegans, but almost no conservation of gene order. Short and long-read transcriptome sequencing allowed us to define coordinated transcriptional regulation throughout the parasite's life cyc","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Nov","modification":"2026-05-02T23:43:12.546Z","creation":"2020-11-19T16:13:36Z"},"accession":"S-EPMC7652881","cross_references":{"pubmed":["33168940"],"doi":["10.1038/s42003-020-01377-3"]}}