biostudies-literatureUnknown9(5)Liang C<h4>Background</h4>Lung cancer is one of the most common cancers in the word. However, the underlying mechanism remains largely unknown. <i>ACOT11</i> encodes enzymes hydrolyzing the fatty acyl-CoA esters into free fatty acids and CoA. Besides from its role in fatty acid metabolism, the other aspects regarding its function in the progression of lung cancer have not been revealed.<h4>Methods</h4>We first explored the clinical profile of <i>ACOT11</i> in tumor samples. Next, we combined gene knockdown <i>in vitro</i> and <i>in vivo</i> and microarray gene profiling analysis to decipher the unknown regulatory role of <i>ACOT11</i> in lung cancer carcinoma. Furthermore, we explored the potential molecular mechanisms of <i>ACOT11</i> with immunoprecipitation.<h4>Results</h4>We found high expresTranslational lung cancer research1885-1903https://www.ebi.ac.uk/biostudies/studies/S-EPMC7653140biostudies-literatureACOT11 promotes cell proliferation, migration and invasion in lung adenocarcinoma.PMC7653140Liang CMa QZhang ZHuang JFeng HZhong DQiang GXiao FWang XLiu DfalseACOT11 promotes cell proliferation, migration and invasion in lung adenocarcinoma.<h4>Background</h4>Lung cancer is one of the most common cancers in the word. However, the underlying mechanism remains largely unknown. <i>ACOT11</i> encodes enzymes hydrolyzing the fatty acyl-CoA esters into free fatty acids and CoA. Besides from its role in fatty acid metabolism, the other aspects regarding its function in the progression of lung cancer have not been revealed.<h4>Methods</h4>We first explored the clinical profile of <i>ACOT11</i> in tumor samples. Next, we combined gene knockdown <i>in vitro</i> and <i>in vivo</i> and microarray gene profiling analysis to decipher the unknown regulatory role of <i>ACOT11</i> in lung cancer carcinoma. Furthermore, we explored the potential molecular mechanisms of <i>ACOT11</i> with immunoprecipitation.<h4>Results</h4>We found high expres2020-01-01T00:00:00Z2020 Oct2025-04-04T23:47:04.398Z2025-04-04T23:47:04.398ZS-EPMC76531403320961010.21037/tlcr-19-509