biostudies-literatureChen BNational Natural Science Foundation of ChinaApplied Basic Research Foundation of Yunnan Provincee0242173https://www.ebi.ac.uk/biostudies/studies/S-EPMC7654825biostudies-literatureUnknown15(11)<h4>Background</h4>Many previous studies have revealed that tumour-infiltrating lymphocytes (TILs) are significantly associated with prognosis in various tumours. However, this finding remains controversial in non-small cell lung cancer (NSCLC). We performed this meta-analysis systematically to evaluate the prognostic value of TILs in NSCLC.<h4>Methods</h4>The references were collected by searching the PubMed, EMBASE and Web of Science databases. The pooled hazard ratios (HRs) with 95% confidence intervals (CIs) were summarized using random or fixed effects models to evaluate the association between TILs and NSCLC survival outcomes.<h4>Results</h4>A total of 45 interrelated studies were eligible that included 11,448 patients. Pooled analysis showed that a high density of TILs indicated a bPloS onePrognostic value of the common tumour-infiltrating lymphocyte subtypes for patients with non-small cell lung cancer: A meta-analysis.PMC7654825817605542018FE001(-247)81960322Li GLi HWang SWu AXiang XLiu CShen YChen BfalsePrognostic value of the common tumour-infiltrating lymphocyte subtypes for patients with non-small cell lung cancer: A meta-analysis.<h4>Background</h4>Many previous studies have revealed that tumour-infiltrating lymphocytes (TILs) are significantly associated with prognosis in various tumours. However, this finding remains controversial in non-small cell lung cancer (NSCLC). We performed this meta-analysis systematically to evaluate the prognostic value of TILs in NSCLC.<h4>Methods</h4>The references were collected by searching the PubMed, EMBASE and Web of Science databases. The pooled hazard ratios (HRs) with 95% confidence intervals (CIs) were summarized using random or fixed effects models to evaluate the association between TILs and NSCLC survival outcomes.<h4>Results</h4>A total of 45 interrelated studies were eligible that included 11,448 patients. Pooled analysis showed that a high density of TILs indicated a b2020-01-01T00:00:00Z20202025-05-29T22:20:16.459Z2025-05-29T22:20:16.459ZS-EPMC76548253317090110.1371/journal.pone.0242173