biostudies-literatureHeissam KU.S. Food and Drug Administratione0241441https://www.ebi.ac.uk/biostudies/studies/S-EPMC7657519biostudies-literatureUnknown15(11)<h4>Objective</h4>The gastrointestinal environment in which drug products need to disintegrate before the drug can dissolve and be absorbed has not been studied in detail due to limitations, especially invasiveness of existing techniques. Minimal in vivo data is available on undisturbed gastrointestinal motility to improve relevance of predictive dissolution models and in silico tools such as physiologically-based pharmacokinetic models. Recent advances in magnetic resonance imaging methods could provide novel data and insights that can be used as a reference to validate and, if necessary, optimize these models. The conventional method for measuring gastrointestinal motility is via a manometric technique involving intubation. Nevertheless, it is feasible to measure gastrointestinal motilitPloS oneMeasurement of fasted state gastric antral motility before and after a standard bioavailability and bioequivalence 240 mL drink of water: Validation of MRI method against concomitant perfused manometry in healthy participants.PMC7657519HHSF223201510157CHeissam KHebbard GAbrehart NBrasseur JGGlover PMDickens JGowland PAMarciani LHoad CLShedden KMenys ASpiller RCBaker JCorsetti MAmidon GEWright JHasler WLMurray KHens BAmidon GLMudie DMfalseMeasurement of fasted state gastric antral motility before and after a standard bioavailability and bioequivalence 240 mL drink of water: Validation of MRI method against concomitant perfused manometry in healthy participants.<h4>Objective</h4>The gastrointestinal environment in which drug products need to disintegrate before the drug can dissolve and be absorbed has not been studied in detail due to limitations, especially invasiveness of existing techniques. Minimal in vivo data is available on undisturbed gastrointestinal motility to improve relevance of predictive dissolution models and in silico tools such as physiologically-based pharmacokinetic models. Recent advances in magnetic resonance imaging methods could provide novel data and insights that can be used as a reference to validate and, if necessary, optimize these models. The conventional method for measuring gastrointestinal motility is via a manometric technique involving intubation. Nevertheless, it is feasible to measure gastrointestinal motilit2020-01-01T00:00:00Z20202026-05-04T23:47:12.118Z2020-11-22T09:41:51ZS-EPMC76575193317586010.1371/journal.pone.0241441