{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Cunha C"],"funding":["NICHD NIH HHS","NIDA NIH HHS","NIMH NIH HHS","U.S. Department of Health & Human Services | NIH | National Institute on Drug Abuse","U.S. Department of Health & Human Services | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development"],"pagination":["4795-4812"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7657958"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["26(9)"],"pubmed_abstract":["Serotonin and dopamine are associated with multiple psychiatric disorders. How they interact during development to affect subsequent behavior remains unknown. Knockout of the serotonin transporter or postnatal blockade with selective serotonin reuptake inhibitors (SSRIs) leads to novelty-induced exploration deficits in adulthood, potentially involving the dopamine system. Here, we show in the mouse that raphe nucleus serotonin neurons activate ventral tegmental area dopamine neurons via glutamate co-transmission and that this co-transmission is reduced in animals exposed postnatally to SSRIs. Blocking serotonin neuron glutamate co-transmission mimics this SSRI-induced hypolocomotion, while optogenetic activation of dopamine neurons reverses this hypolocomotor phenotype. Our data demonstrat"],"journal":["Molecular psychiatry"],"pubmed_title":["Perinatal interference with the serotonergic system affects VTA function in the adult via glutamate co-transmission."],"pmcid":["PMC7657958"],"funding_grant_id":["R01 HD095966","R01 MH117128","R01 DA038966","R03 HD094978"],"pubmed_authors":["Chuhma N","Castellanos FX","Edwards RH","Menezes EC","Ansorge MS","Seal RP","Shah R","Smiley JF","Bleiwas C","Rayport S","Cunha C","Teixeira CM"],"additional_accession":[]},"is_claimable":false,"name":"Perinatal interference with the serotonergic system affects VTA function in the adult via glutamate co-transmission.","description":"Serotonin and dopamine are associated with multiple psychiatric disorders. How they interact during development to affect subsequent behavior remains unknown. Knockout of the serotonin transporter or postnatal blockade with selective serotonin reuptake inhibitors (SSRIs) leads to novelty-induced exploration deficits in adulthood, potentially involving the dopamine system. Here, we show in the mouse that raphe nucleus serotonin neurons activate ventral tegmental area dopamine neurons via glutamate co-transmission and that this co-transmission is reduced in animals exposed postnatally to SSRIs. Blocking serotonin neuron glutamate co-transmission mimics this SSRI-induced hypolocomotion, while optogenetic activation of dopamine neurons reverses this hypolocomotor phenotype. Our data demonstrat","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Sep","modification":"2025-04-21T21:29:51.696Z","creation":"2022-02-11T14:52:10.518Z"},"accession":"S-EPMC7657958","cross_references":{"pubmed":["32398719"],"doi":["10.1038/s41380-020-0763-z"]}}