{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["9(5)"],"submitter":["Wei X"],"pubmed_abstract":["<h4>Background</h4>Autophagy was a significant catabolic process which played a critical role in the maintenance of cellular homeostasis and viability in a stressed state. The dysregulation of autophagy was correlated with various diseases. The aim of our study was to develop a prognostic signature for papillary renal cell carcinoma (RCC).<h4>Methods</h4>First, 40 differently expressed genes related with autophagy (ARGs) were examined via high-throughput sequencing and large-scale databases. Then, functional enrichment analysis was performed to explore the biological attributes of these ARGs. The Cox proportional hazard regression hinted that four ARGs (<i>P4HB</i>, <i>BIRC5</i>, <i>NGR1</i> and <i>PRKN</i>) were significantly correlated with overall survival (OS). Thus, we got genes with prognostic value. Finally, a prognostic index (PI) was constructed.<h4>Results</h4>After identifying the 4 ARGs, we profiled our risk signature. Based on the PI we developed, papillary RCC patients were stratified into high-risk and low-risk groups. High-risk patients had significant shorter OS than low-risk patients (P<0.001) and the mortality of high scoring patients was higher than low scoring patients. Additionally, we explored the relationship between the 4 ARGs and clinical parameters and found that the expression of <i>P4HB</i>, <i>BIRC5</i> and <i>NGR1</i> was correlated with clinicopathological features.<h4>Conclusions</h4>Our study suggested that the four-gene signature was an independent prognostic factor which could act as a novel indicator for the prognosis of papillary RCC."],"journal":["Translational andrology and urology"],"pagination":["1945-1956"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7658136"],"repository":["biostudies-literature"],"pubmed_title":["Identification of an independent autophagy-gene prognostic index for papillary renal cell carcinoma."],"pmcid":["PMC7658136"],"pubmed_authors":["Li G","Ren X","Ji C","Song N","Wei X","Wang W","Wang H","Wang Y","Qin C"],"additional_accession":[]},"is_claimable":false,"name":"Identification of an independent autophagy-gene prognostic index for papillary renal cell carcinoma.","description":"<h4>Background</h4>Autophagy was a significant catabolic process which played a critical role in the maintenance of cellular homeostasis and viability in a stressed state. The dysregulation of autophagy was correlated with various diseases. The aim of our study was to develop a prognostic signature for papillary renal cell carcinoma (RCC).<h4>Methods</h4>First, 40 differently expressed genes related with autophagy (ARGs) were examined via high-throughput sequencing and large-scale databases. Then, functional enrichment analysis was performed to explore the biological attributes of these ARGs. The Cox proportional hazard regression hinted that four ARGs (<i>P4HB</i>, <i>BIRC5</i>, <i>NGR1</i> and <i>PRKN</i>) were significantly correlated with overall survival (OS). Thus, we got genes with prognostic value. Finally, a prognostic index (PI) was constructed.<h4>Results</h4>After identifying the 4 ARGs, we profiled our risk signature. Based on the PI we developed, papillary RCC patients were stratified into high-risk and low-risk groups. High-risk patients had significant shorter OS than low-risk patients (P<0.001) and the mortality of high scoring patients was higher than low scoring patients. Additionally, we explored the relationship between the 4 ARGs and clinical parameters and found that the expression of <i>P4HB</i>, <i>BIRC5</i> and <i>NGR1</i> was correlated with clinicopathological features.<h4>Conclusions</h4>Our study suggested that the four-gene signature was an independent prognostic factor which could act as a novel indicator for the prognosis of papillary RCC.","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Oct","modification":"2026-06-12T09:53:44.384Z","creation":"2025-04-19T23:41:02.088Z"},"accession":"S-EPMC7658136","cross_references":{"pubmed":["33209659"],"doi":["10.21037/tau-20-906"]}}