biostudies-literatureUnknown9(5)Wei X<h4>Background</h4>Autophagy was a significant catabolic process which played a critical role in the maintenance of cellular homeostasis and viability in a stressed state. The dysregulation of autophagy was correlated with various diseases. The aim of our study was to develop a prognostic signature for papillary renal cell carcinoma (RCC).<h4>Methods</h4>First, 40 differently expressed genes related with autophagy (ARGs) were examined via high-throughput sequencing and large-scale databases. Then, functional enrichment analysis was performed to explore the biological attributes of these ARGs. The Cox proportional hazard regression hinted that four ARGs (<i>P4HB</i>, <i>BIRC5</i>, <i>NGR1</i> and <i>PRKN</i>) were significantly correlated with overall survival (OS). Thus, we got genes with prognostic value. Finally, a prognostic index (PI) was constructed.<h4>Results</h4>After identifying the 4 ARGs, we profiled our risk signature. Based on the PI we developed, papillary RCC patients were stratified into high-risk and low-risk groups. High-risk patients had significant shorter OS than low-risk patients (P<0.001) and the mortality of high scoring patients was higher than low scoring patients. Additionally, we explored the relationship between the 4 ARGs and clinical parameters and found that the expression of <i>P4HB</i>, <i>BIRC5</i> and <i>NGR1</i> was correlated with clinicopathological features.<h4>Conclusions</h4>Our study suggested that the four-gene signature was an independent prognostic factor which could act as a novel indicator for the prognosis of papillary RCC.Translational andrology and urology1945-1956https://www.ebi.ac.uk/biostudies/studies/S-EPMC7658136biostudies-literatureIdentification of an independent autophagy-gene prognostic index for papillary renal cell carcinoma.PMC7658136Li GRen XJi CSong NWei XWang WWang HWang YQin CfalseIdentification of an independent autophagy-gene prognostic index for papillary renal cell carcinoma.<h4>Background</h4>Autophagy was a significant catabolic process which played a critical role in the maintenance of cellular homeostasis and viability in a stressed state. The dysregulation of autophagy was correlated with various diseases. The aim of our study was to develop a prognostic signature for papillary renal cell carcinoma (RCC).<h4>Methods</h4>First, 40 differently expressed genes related with autophagy (ARGs) were examined via high-throughput sequencing and large-scale databases. Then, functional enrichment analysis was performed to explore the biological attributes of these ARGs. The Cox proportional hazard regression hinted that four ARGs (<i>P4HB</i>, <i>BIRC5</i>, <i>NGR1</i> and <i>PRKN</i>) were significantly correlated with overall survival (OS). Thus, we got genes with prognostic value. Finally, a prognostic index (PI) was constructed.<h4>Results</h4>After identifying the 4 ARGs, we profiled our risk signature. Based on the PI we developed, papillary RCC patients were stratified into high-risk and low-risk groups. High-risk patients had significant shorter OS than low-risk patients (P<0.001) and the mortality of high scoring patients was higher than low scoring patients. Additionally, we explored the relationship between the 4 ARGs and clinical parameters and found that the expression of <i>P4HB</i>, <i>BIRC5</i> and <i>NGR1</i> was correlated with clinicopathological features.<h4>Conclusions</h4>Our study suggested that the four-gene signature was an independent prognostic factor which could act as a novel indicator for the prognosis of papillary RCC.2020-01-01T00:00:00Z2020 Oct2026-06-12T09:53:44.384Z2025-04-19T23:41:02.088ZS-EPMC76581363320965910.21037/tau-20-906