biostudies-literatureSanta-Marina LDepartment of Health of the Basque GovernmentGeneralitat de CatalunyaFundació La marató de TV3Instituto de Salud Carlos IIIEuropean UnionAlicia Koplowitz FoundationE7704https://www.ebi.ac.uk/biostudies/studies/S-EPMC7659477biostudies-literatureUnknown17(21)Ferritin status during prenatal brain development may influence the risk of attention deficit and hyperactivity disorder (ADHD) symptoms in childhood. We investigated the association of maternal ferritin in pregnancy and ADHD-like symptoms in offspring. A total of 1095 mother-child pairs from three birth cohorts of the INMA Project (Spain) were studied. Maternal plasma ferritin in pregnancy was measured at 11.57 weeks of gestation. Children's ADHD-like symptoms at ages 4-5 years were assessed using the ADHD Rating Scale-IV. The count model of the zero-inflated Poisson regression model showed a significant inverse association between ferritin (continuous variable) and inattention, β = -0.19 (-0.32, -0.07), for boys. Comparing ferritin level by tertiles, significant differences were observedInternational journal of environmental research and public healthMaternal Ferritin Levels during Pregnancy and ADHD Symptoms in 4-Year-Old Children: Results from the INMA-INfancia y Medio Ambiente (Environment and Childhood) Prospective Birth Cohort Study.PMC7659477Miguel Servet-European Regional Development Fund CP11/00178, CP15/00025, and MSII16/00051Red INMA G03/176; CB06/02/0041; PI041436; and PI081151 including support from the European Regional Development Fund (ERDF2017FP7-ENV-2011, grant number: 282957 and HEALTH.2010.2.4.5-12005111093, 2009111069 and 20131110891999SGR 00241UGP 15-230, UGP-15-244, and UGP-15-249CERCA Programme090430DFG06/002 and DFG08/001FIS-PI06/0867, FIS-PI09/00090 and FIS-PI13/02187G03/176; FIS-ERDF: PI11/01007, PI11/02591, PI11/02038, PI12/00610, PI13/1944, PI13/2032, PI14/00891, PI14/01687, PI16/1288, and PI17/00663Irizar ALlop SSanta-Marina LImaz LFerrin MAndiarena ALertxundi NBeneito AIbarluzea JSunyer JJulvez JMolinuevo AfalseMaternal Ferritin Levels during Pregnancy and ADHD Symptoms in 4-Year-Old Children: Results from the INMA-INfancia y Medio Ambiente (Environment and Childhood) Prospective Birth Cohort Study.Ferritin status during prenatal brain development may influence the risk of attention deficit and hyperactivity disorder (ADHD) symptoms in childhood. We investigated the association of maternal ferritin in pregnancy and ADHD-like symptoms in offspring. A total of 1095 mother-child pairs from three birth cohorts of the INMA Project (Spain) were studied. Maternal plasma ferritin in pregnancy was measured at 11.57 weeks of gestation. Children's ADHD-like symptoms at ages 4-5 years were assessed using the ADHD Rating Scale-IV. The count model of the zero-inflated Poisson regression model showed a significant inverse association between ferritin (continuous variable) and inattention, β = -0.19 (-0.32, -0.07), for boys. Comparing ferritin level by tertiles, significant differences were observed2020-01-01T00:00:00Z2020 Oct2025-04-22T15:00:24.365Z2020-11-19T11:37:56ZS-EPMC76594773310557210.3390/ijerph17217704