{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["6(10)"],"submitter":["Bussotti G"],"funding":["Institut Pasteur"],"pubmed_abstract":["Although several studies have investigated genetic diversity of <i>Leishmania infantum</i> in North Africa, genome-wide analyses are lacking. Here, we conducted comparative analyses of nuclear and mitochondrial genomes of seven <i>L</i>. <i>infantum</i> isolates from Tunisia with the aim to gain insight into factors that drive genomic and phenotypic adaptation. Isolates were from cured (<i>n</i>=4) and recurrent (<i>n</i>=3) visceral leishmaniasis (VL) cases, originating from northern (<i>n</i>=2) and central (<i>n</i>=5) Tunisia, where respectively stable and emerging VL foci are observed. All isolates from relapsed patients were from Kairouan governorate (Centre); one showing resistance to the anti-leishmanial drug Meglumine antimoniate. Nuclear genome diversity of the isolates was analy"],"journal":["Microbial genomics"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7660250"],"repository":["biostudies-literature"],"pubmed_title":["Nuclear and mitochondrial genome sequencing of North-African <i>Leishmania infantum</i> isolates from cured and relapsed visceral leishmaniasis patients reveals variations correlating with geography and phenotype."],"pmcid":["PMC7660250"],"pubmed_authors":["Benkahla A","Jeddi F","Spath GF","Souiai O","Bouratbine A","Bussotti G","Aoun K"],"additional_accession":[]},"is_claimable":false,"name":"Nuclear and mitochondrial genome sequencing of North-African <i>Leishmania infantum</i> isolates from cured and relapsed visceral leishmaniasis patients reveals variations correlating with geography and phenotype.","description":"Although several studies have investigated genetic diversity of <i>Leishmania infantum</i> in North Africa, genome-wide analyses are lacking. Here, we conducted comparative analyses of nuclear and mitochondrial genomes of seven <i>L</i>. <i>infantum</i> isolates from Tunisia with the aim to gain insight into factors that drive genomic and phenotypic adaptation. Isolates were from cured (<i>n</i>=4) and recurrent (<i>n</i>=3) visceral leishmaniasis (VL) cases, originating from northern (<i>n</i>=2) and central (<i>n</i>=5) Tunisia, where respectively stable and emerging VL foci are observed. All isolates from relapsed patients were from Kairouan governorate (Centre); one showing resistance to the anti-leishmanial drug Meglumine antimoniate. Nuclear genome diversity of the isolates was analy","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Oct","modification":"2026-05-02T19:18:05.555Z","creation":"2020-11-19T17:00:20Z"},"accession":"S-EPMC7660250","cross_references":{"pubmed":["32975503"],"doi":["10.1099/mgen.0.000444"]}}