biostudies-literatureWu JYFood and Health BureauShenzhen Science and Technology Innovation Commission341https://www.ebi.ac.uk/biostudies/studies/S-EPMC7661185biostudies-literatureUnknown20(1)<h4>Background</h4>Herba Siegesbeckiae (HS), the dried aerial parts of Siegesbeckia orientalis L., S. pubescens Makino, or S. glabrescens Makino, is traditionally used for treating chronic diseases in China. However, there is no information about the chronic toxicity of HS. The objective of this study is to evaluate the 24-week oral dosing toxicities of HS aqueous extract (HSE) in rats.<h4>Methods</h4>S. orientalis-originated HS was reflux-extracted with distilled water. Sprague-Dawley rats were randomly divided into four groups, with 10 males and 10 females in each group. The rats were intragastrically administered with HSE at 5, 1.67 and 0.56 g/kg (experimental groups) or an equal volume of distilled water (control group), 6 days a week, for 24 weeks. The high dose of HSE (5 g/kg) was itBMC complementary medicine and therapiesTwenty-four-week oral dosing toxicities of Herba Siegesbeckiae in rats.PMC7661185No. 11122521JCYJ20170817173608483Yi HGuo HChen YJChan YCLiu YXYu ZLWu JYfalseTwenty-four-week oral dosing toxicities of Herba Siegesbeckiae in rats.<h4>Background</h4>Herba Siegesbeckiae (HS), the dried aerial parts of Siegesbeckia orientalis L., S. pubescens Makino, or S. glabrescens Makino, is traditionally used for treating chronic diseases in China. However, there is no information about the chronic toxicity of HS. The objective of this study is to evaluate the 24-week oral dosing toxicities of HS aqueous extract (HSE) in rats.<h4>Methods</h4>S. orientalis-originated HS was reflux-extracted with distilled water. Sprague-Dawley rats were randomly divided into four groups, with 10 males and 10 females in each group. The rats were intragastrically administered with HSE at 5, 1.67 and 0.56 g/kg (experimental groups) or an equal volume of distilled water (control group), 6 days a week, for 24 weeks. The high dose of HSE (5 g/kg) was it2020-01-01T00:00:00Z2020 Nov2025-06-01T01:16:33.981Z2020-11-19T15:26:02ZS-EPMC76611853317678210.1186/s12906-020-03137-6