biostudies-literatureUnknown7Robert M<b>Objective:</b> Rheumatoid arthritis (RA) leads not only to joint destruction but also to systemic manifestations, with an increased incidence of cardiovascular events (CVE). Many studies have shown a link between RA severity and CV risk, but the duration of follow-up remains often insufficient to allow a conclusion. The CVE definition was generally reduced to myocardial infarction and stroke, and few studies were conducted in non-Anglo-Saxon countries with low CV incidence. This study aimed to assess the relationship between joint destruction and the occurrence of different types of CVE in a large cohort of French RA patients with a long-term follow-up. <b>Methods:</b> This historical cohort study included 571 RA patients followed between 1992 and 2012 in Lyon, France. The primary endpoFrontiers in medicine556086https://www.ebi.ac.uk/biostudies/studies/S-EPMC7661545biostudies-literatureJoint Destruction Is Associated With All Types of Cardiovascular Events in French Rheumatoid Patients: A Real-Life Study With Very Long Follow-Up.PMC7661545Hot AMiossec PRobert MMifsud FNdongo-Thiam NfalseJoint Destruction Is Associated With All Types of Cardiovascular Events in French Rheumatoid Patients: A Real-Life Study With Very Long Follow-Up.<b>Objective:</b> Rheumatoid arthritis (RA) leads not only to joint destruction but also to systemic manifestations, with an increased incidence of cardiovascular events (CVE). Many studies have shown a link between RA severity and CV risk, but the duration of follow-up remains often insufficient to allow a conclusion. The CVE definition was generally reduced to myocardial infarction and stroke, and few studies were conducted in non-Anglo-Saxon countries with low CV incidence. This study aimed to assess the relationship between joint destruction and the occurrence of different types of CVE in a large cohort of French RA patients with a long-term follow-up. <b>Methods:</b> This historical cohort study included 571 RA patients followed between 1992 and 2012 in Lyon, France. The primary endpo2020-01-01T00:00:00Z20202025-04-26T06:13:08.077Z2020-11-19T15:25:19ZS-EPMC76615453319530610.3389/fmed.2020.556086