{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13(1)"],"submitter":["Shelby A"],"pubmed_abstract":["<h4>Objective</h4>PD-L1 is an immune checkpoint molecule that regulates immune and inflammatory responses. While cells of periodontal tissues express PD-L1, its presence in GCF is not known. The purpose of this study was to measure the PD-L1 values in GCF and correlate values with the presence of chemokine and cytokine values from periodontally diseased subjects and periodontally healthy subjects.<h4>Results</h4>PD-L1 values (pg/30 s), determined in triplicate using a fluorescent microparticle-based immunoassay ranged from 0.04-31.65 pg/30 s. PD-L1 correlated with 15 out of 22 chemokine and cytokine responses. In 85 healthy sites in 31 subjects, PD-L1 values were negatively correlated with IL6, CXCL8, IL10, and CCL3 values. In 53 diseased sites in 20 subjects, PD-L1 values were positively "],"journal":["BMC research notes"],"pagination":["532"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7666489"],"repository":["biostudies-literature"],"pubmed_title":["PD-L1 correlates with chemokines and cytokines in gingival crevicular fluid from healthy and diseased sites in subjects with periodontitis."],"pmcid":["PMC7666489"],"pubmed_authors":["Brogden KA","Shelby A","Thayer E","Johnson GK","Pendleton C","Xie XJ"],"additional_accession":[]},"is_claimable":false,"name":"PD-L1 correlates with chemokines and cytokines in gingival crevicular fluid from healthy and diseased sites in subjects with periodontitis.","description":"<h4>Objective</h4>PD-L1 is an immune checkpoint molecule that regulates immune and inflammatory responses. While cells of periodontal tissues express PD-L1, its presence in GCF is not known. The purpose of this study was to measure the PD-L1 values in GCF and correlate values with the presence of chemokine and cytokine values from periodontally diseased subjects and periodontally healthy subjects.<h4>Results</h4>PD-L1 values (pg/30 s), determined in triplicate using a fluorescent microparticle-based immunoassay ranged from 0.04-31.65 pg/30 s. PD-L1 correlated with 15 out of 22 chemokine and cytokine responses. In 85 healthy sites in 31 subjects, PD-L1 values were negatively correlated with IL6, CXCL8, IL10, and CCL3 values. In 53 diseased sites in 20 subjects, PD-L1 values were positively ","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Nov","modification":"2025-04-22T05:32:36.867Z","creation":"2025-04-05T21:21:58.461Z"},"accession":"S-EPMC7666489","cross_references":{"pubmed":["33187554"],"doi":["10.1186/s13104-020-05376-9"]}}