biostudies-literatureUnknown9(5)Jimenez-Tornero J<h4>Background</h4>Evidence suggests that a preoperative single-dose steroid improves lung function and decreases the incidence of postoperative symptoms; however, this has not been sufficiently proved in modified radical mastectomy for cancer. This study aimed to evaluate the efficacy of preoperative single-dose steroid administration for postoperative lung function and postoperative symptoms in women undergoing modified radical mastectomy for breast cancer.<h4>Methods</h4>In this controlled clinical trial, conducted between June 2014 and October 2018, we examined 81 patients. Patients received a preoperative single dose of 8 mg dexamethasone (n=41; treatment group) or placebo (sterile injectable water; n=40; control group). We obtained data on postoperative nausea and vomiting and pain iGland surgery1313-1327https://www.ebi.ac.uk/biostudies/studies/S-EPMC7667090biostudies-literatureEffect of a preoperative single-dose steroid on pulmonary function and postoperative symptoms after modified radical mastectomy: results of a randomized clinical trial.PMC7667090Zuloaga-Fernandez Del Valle CMiranda-Ackerman RCCortes-Flores AOMorgan-Villela GFernandez-Avalos VSChavez-Tostado MFuentes-Orozco CJimenez-Tornero JZuloaga-Fernandez Del Valle RGarcia-Gonzalez LAAlvarez-Villasenor ASContreras-Cordero VSGonzalez-Ojeda ABarbosa-Camacho FJAmbriz-Gonzalez GfalseEffect of a preoperative single-dose steroid on pulmonary function and postoperative symptoms after modified radical mastectomy: results of a randomized clinical trial.<h4>Background</h4>Evidence suggests that a preoperative single-dose steroid improves lung function and decreases the incidence of postoperative symptoms; however, this has not been sufficiently proved in modified radical mastectomy for cancer. This study aimed to evaluate the efficacy of preoperative single-dose steroid administration for postoperative lung function and postoperative symptoms in women undergoing modified radical mastectomy for breast cancer.<h4>Methods</h4>In this controlled clinical trial, conducted between June 2014 and October 2018, we examined 81 patients. Patients received a preoperative single dose of 8 mg dexamethasone (n=41; treatment group) or placebo (sterile injectable water; n=40; control group). We obtained data on postoperative nausea and vomiting and pain i2020-01-01T00:00:00Z2020 Oct2025-04-04T22:52:51.124Z2021-02-19T23:59:42ZS-EPMC76670903322480610.21037/gs-20-366