{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Galeano Nino JL"],"funding":["NSERC","National Health and Medical Research Council","University of Sydney","EMBL Australia"],"pagination":["e56554"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7669268"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["9"],"pubmed_abstract":["Cytotoxic T lymphocytes (CTLs) are thought to arrive at target sites either via random search or following signals by other leukocytes. Here, we reveal independent emergent behaviour in CTL populations attacking tumour masses. Primary murine CTLs coordinate their migration in a process reminiscent of the swarming observed in neutrophils. CTLs engaging cognate targets accelerate the recruitment of distant T cells through long-range homotypic signalling, in part mediated via the diffusion of chemokines CCL3 and CCL4. Newly arriving CTLs augment the chemotactic signal, further accelerating mass recruitment in a positive feedback loop. Activated effector human T cells and chimeric antigen receptor (CAR) T cells similarly employ intra-population signalling to drive rapid convergence. Thus, CTLs"],"journal":["eLife"],"pubmed_title":["Cytotoxic T cells swarm by homotypic chemokine signalling."],"pmcid":["PMC7669268"],"funding_grant_id":["Centre for Advanced Food Enginomics","RGPIN 50503-10477","50503-10476","GNT1135687"],"pubmed_authors":["Rice G","Rizzetto S","Zieba J","Cremasco J","Galeano Nino JL","Mazalo JK","Luciani F","Pageon SV","Govendir MA","Kempe D","Biro M","Hywood J","Tay SS","Webb AI","O'Neill GM","Nisbet DR","Prior V","Kramer B","Read MN","Colakoglu F","Dagley LF","Williams RJ","Hsu K"],"additional_accession":[]},"is_claimable":false,"name":"Cytotoxic T cells swarm by homotypic chemokine signalling.","description":"Cytotoxic T lymphocytes (CTLs) are thought to arrive at target sites either via random search or following signals by other leukocytes. Here, we reveal independent emergent behaviour in CTL populations attacking tumour masses. Primary murine CTLs coordinate their migration in a process reminiscent of the swarming observed in neutrophils. CTLs engaging cognate targets accelerate the recruitment of distant T cells through long-range homotypic signalling, in part mediated via the diffusion of chemokines CCL3 and CCL4. Newly arriving CTLs augment the chemotactic signal, further accelerating mass recruitment in a positive feedback loop. Activated effector human T cells and chimeric antigen receptor (CAR) T cells similarly employ intra-population signalling to drive rapid convergence. Thus, CTLs","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Oct","modification":"2026-04-28T22:23:18.303Z","creation":"2020-11-22T09:41:27Z"},"accession":"S-EPMC7669268","cross_references":{"pubmed":["33046212"],"doi":["10.7554/eLife.56554"]}}