{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["16(11)"],"submitter":["Balachandra VK"],"pubmed_abstract":["Regulation of gene expression programs is crucial for the survival of microbial pathogens in host environments and for their ability to cause disease. Here we investigated the epigenetic regulator RSC (Remodels the Structure of Chromatin) in the most prevalent human fungal pathogen Candida albicans. Biochemical analysis showed that CaRSC comprises 13 subunits and contains two novel non-essential members, which we named Nri1 and Nri2 (Novel RSC Interactors) that are exclusive to the CTG clade of Saccharomycotina. Genetic analysis showed distinct essentiality of C. albicans RSC subunits compared to model fungal species suggesting functional and structural divergence of RSC functions in this fungal pathogen. Transcriptomic and proteomic profiling of a conditional mutant of the essential catal"],"journal":["PLoS genetics"],"pagination":["e1009071"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7671503"],"repository":["biostudies-literature"],"pubmed_title":["The RSC (Remodels the Structure of Chromatin) complex of Candida albicans shows compositional divergence with distinct roles in regulating pathogenic traits."],"pmcid":["PMC7671503"],"pubmed_authors":["Traven A","Tucey TM","Schittenhelm RB","Shankar M","Verma J","Ghosh SK","Balachandra VK"],"additional_accession":[]},"is_claimable":false,"name":"The RSC (Remodels the Structure of Chromatin) complex of Candida albicans shows compositional divergence with distinct roles in regulating pathogenic traits.","description":"Regulation of gene expression programs is crucial for the survival of microbial pathogens in host environments and for their ability to cause disease. Here we investigated the epigenetic regulator RSC (Remodels the Structure of Chromatin) in the most prevalent human fungal pathogen Candida albicans. Biochemical analysis showed that CaRSC comprises 13 subunits and contains two novel non-essential members, which we named Nri1 and Nri2 (Novel RSC Interactors) that are exclusive to the CTG clade of Saccharomycotina. Genetic analysis showed distinct essentiality of C. albicans RSC subunits compared to model fungal species suggesting functional and structural divergence of RSC functions in this fungal pathogen. Transcriptomic and proteomic profiling of a conditional mutant of the essential catal","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Nov","modification":"2025-04-19T23:24:45.288Z","creation":"2021-02-19T10:11:54Z"},"accession":"S-EPMC7671503","cross_references":{"pubmed":["33151931"],"doi":["10.1371/journal.pgen.1009071"]}}