{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Duprilot M"],"funding":["Agence Nationale de la Recherche","Fondation de la Recherche Médicale","Spanish Ministerio de Educacion"],"pagination":["e00576-20"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7671891"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["88(12)"],"pubmed_abstract":["<i>Escherichia coli</i> O25b:H4 sequence type 131 (ST131), which is resistant to fluoroquinolones and which is a producer of CTX-M-15, is globally one of the major extraintestinal pathogenic <i>E. coli</i> (ExPEC) lineages. Phylogenetic analyses showed that multidrug-resistant ST131 strains belong to clade C, which recently emerged from clade B by stepwise evolution. It has been hypothesized that features other than multidrug resistance could contribute to this dissemination since other major global ExPEC lineages (ST73 and ST95) are mostly antibiotic susceptible. To test this hypothesis, we compared early biofilm production, presence of ExPEC virulence factors (VFs), and <i>in vivo</i> virulence in a mouse sepsis model in 19 and 20 epidemiologically relevant strains of clades B and C, res"],"journal":["Infection and immunity"],"pubmed_title":["Success of Escherichia coli O25b:H4 Sequence Type 131 Clade C Associated with a Decrease in Virulence."],"pmcid":["PMC7671891"],"funding_grant_id":["FPU 15/02644","DEQ 20161136698","ANR-16 JPEC-0002-04"],"pubmed_authors":["Pouget C","Flament-Simon SC","Dion S","Denamur E","Baron A","Letteron P","Clermont O","Blanquart F","Duprilot M","Nicolas-Chanoine MH"],"additional_accession":[]},"is_claimable":false,"name":"Success of Escherichia coli O25b:H4 Sequence Type 131 Clade C Associated with a Decrease in Virulence.","description":"<i>Escherichia coli</i> O25b:H4 sequence type 131 (ST131), which is resistant to fluoroquinolones and which is a producer of CTX-M-15, is globally one of the major extraintestinal pathogenic <i>E. coli</i> (ExPEC) lineages. Phylogenetic analyses showed that multidrug-resistant ST131 strains belong to clade C, which recently emerged from clade B by stepwise evolution. It has been hypothesized that features other than multidrug resistance could contribute to this dissemination since other major global ExPEC lineages (ST73 and ST95) are mostly antibiotic susceptible. To test this hypothesis, we compared early biofilm production, presence of ExPEC virulence factors (VFs), and <i>in vivo</i> virulence in a mouse sepsis model in 19 and 20 epidemiologically relevant strains of clades B and C, res","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Nov","modification":"2026-05-02T20:34:54.757Z","creation":"2021-02-20T09:58:42Z"},"accession":"S-EPMC7671891","cross_references":{"pubmed":["32989036"],"doi":["10.1128/IAI.00576-20"]}}