biostudies-literatureRengaraj DNational Research Foundation of KoreaE8170https://www.ebi.ac.uk/biostudies/studies/S-EPMC7672628biostudies-literatureUnknown21(21)The deleted in azoospermia like (<i>DAZL</i>) is required for germ cells development and maintenance. In chickens, the mRNA and protein of <i>DAZL</i>, a representative maternally inherited germ plasm factor, are detected in the germ plasm of oocyte, zygote, and all stages of the intrauterine embryos. However, it is still insufficient to explain the origin and specification process of chicken germ cells, because the stage at which the zygotic transcription of <i>DAZL</i> occurs and the stage at which the maternal <i>DAZL</i> RNA/protein clears have not yet been fully identified. Moreover, a comprehensive understanding of the expression of <i>DAZL</i> interacting genes during the germ cells specification and development and zygotic genome activation (ZGA) is lacking in chickens. In this stuInternational journal of molecular sciencesWhole-Transcriptome Sequencing-Based Analysis of <i>DAZL</i> and Its Interacting Genes during Germ Cells Specification and Zygotic Genome Activation in Chickens.PMC7672628NRF-2015R1A3A2033826NRF-2018R1D1A1B07050287Kim HWon SYoo DRengaraj DHan JYHan JWfalseWhole-Transcriptome Sequencing-Based Analysis of <i>DAZL</i> and Its Interacting Genes during Germ Cells Specification and Zygotic Genome Activation in Chickens.The deleted in azoospermia like (<i>DAZL</i>) is required for germ cells development and maintenance. In chickens, the mRNA and protein of <i>DAZL</i>, a representative maternally inherited germ plasm factor, are detected in the germ plasm of oocyte, zygote, and all stages of the intrauterine embryos. However, it is still insufficient to explain the origin and specification process of chicken germ cells, because the stage at which the zygotic transcription of <i>DAZL</i> occurs and the stage at which the maternal <i>DAZL</i> RNA/protein clears have not yet been fully identified. Moreover, a comprehensive understanding of the expression of <i>DAZL</i> interacting genes during the germ cells specification and development and zygotic genome activation (ZGA) is lacking in chickens. In this stu2020-01-01T00:00:00Z2020 Oct2026-04-07T16:43:29.846Z2020-11-22T09:39:17ZS-EPMC76726283314291810.3390/ijms21218170