biostudies-literaturePan SDSwiss National Science Foundation588195https://www.ebi.ac.uk/biostudies/studies/S-EPMC7674855biostudies-literatureUnknown10<h4>Background</h4>Microglia initiates and sustains the inflammatory reaction that drives the pathogenesis of pneumococcal meningitis. The expression of the G-protein cannabinoid receptor type 2 (CB2) in the brain is low, but is upregulated in glial cells during infection. Its activation down-regulates pro-inflammatory processes, driving microglia towards an anti-inflammatory phenotype. CB2 agonists are therefore therapeutic candidates in inflammatory conditions like pneumococcal meningitis. We evaluated the effects of JWH-133, a specific CB2 agonist on microglial cells, inflammation, and damage driven by <i>S. pneumoniae</i> <i>in vitro</i> and in experimental pneumococcal meningitis.<h4>Materials/methods</h4>Primary mixed glial cultures were stimulated with live or heat-inactivated <i>S.Frontiers in cellular and infection microbiologyAdjuvant Cannabinoid Receptor Type 2 Agonist Modulates the Polarization of Microglia Towards a Non-Inflammatory Phenotype in Experimental Pneumococcal Meningitis.PMC7674855189136Leib SLGrandgirard DPan SDfalseAdjuvant Cannabinoid Receptor Type 2 Agonist Modulates the Polarization of Microglia Towards a Non-Inflammatory Phenotype in Experimental Pneumococcal Meningitis.<h4>Background</h4>Microglia initiates and sustains the inflammatory reaction that drives the pathogenesis of pneumococcal meningitis. The expression of the G-protein cannabinoid receptor type 2 (CB2) in the brain is low, but is upregulated in glial cells during infection. Its activation down-regulates pro-inflammatory processes, driving microglia towards an anti-inflammatory phenotype. CB2 agonists are therefore therapeutic candidates in inflammatory conditions like pneumococcal meningitis. We evaluated the effects of JWH-133, a specific CB2 agonist on microglial cells, inflammation, and damage driven by <i>S. pneumoniae</i> <i>in vitro</i> and in experimental pneumococcal meningitis.<h4>Materials/methods</h4>Primary mixed glial cultures were stimulated with live or heat-inactivated <i>S.2020-01-01T00:00:00Z20202025-04-26T04:19:15.667Z2021-02-20T02:46:22ZS-EPMC76748553325115910.3389/fcimb.2020.588195