biostudies-literatureUnknown27(3)Weis SThüringer Ministerium für Wirtschaft, Wissenschaft und Digitale Gesellschaft<h4>Objectives</h4>Due to a substantial proportion of asymptomatic and mild courses, many severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections remain unreported. Therefore, assessment of seroprevalence may detect the real burden of disease. We aimed to determine and characterize the rate of SARS-CoV-2 infections and the resulting seroprevalence in a defined population. The primary objective of the study was to assess SARS-CoV-2 antibody seroprevalence using six different IgG-detecting immunoassays. Secondary objectives of the study were: (a) to determine potential risk factors for symptomatic versus asymptomatic coronavirus disease 2019 courses, and (b) to investigate the rate of virus RNA-persistence.<h4>Methods</h4>CoNAN is a population-based cohort study performed in Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases470.e1-470.e9https://www.ebi.ac.uk/biostudies/studies/S-EPMC7677041biostudies-literatureAntibody response using six different serological assays in a completely PCR-tested community after a coronavirus disease 2019 outbreak-the CoNAN study.PMC7677041Kiehntopf MMai SRichert CCoNAN Study GroupDeinhardt-Emmer SStotzer KRostel FUllrich MKimmig AProquitte HHotz TBauer MGuerra JRimek DPinkwart CBaier MKosenkow JAndreas NBahrs CLocal Cooperation PartnersKoch RKamradt TCipowicz HKuhn SHanf GGlockner SMeinung BMarquardt RAnkert JLoffler BPletz MWHagel SWeiss DMakarewicz OThieme LKolanos SScherag AWetzker WSchnizer CEibner CLicht AKohler JHartung AEnders PDickmann PWeis SScholz JMuller JfalseAntibody response using six different serological assays in a completely PCR-tested community after a coronavirus disease 2019 outbreak-the CoNAN study.<h4>Objectives</h4>Due to a substantial proportion of asymptomatic and mild courses, many severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections remain unreported. Therefore, assessment of seroprevalence may detect the real burden of disease. We aimed to determine and characterize the rate of SARS-CoV-2 infections and the resulting seroprevalence in a defined population. The primary objective of the study was to assess SARS-CoV-2 antibody seroprevalence using six different IgG-detecting immunoassays. Secondary objectives of the study were: (a) to determine potential risk factors for symptomatic versus asymptomatic coronavirus disease 2019 courses, and (b) to investigate the rate of virus RNA-persistence.<h4>Methods</h4>CoNAN is a population-based cohort study performed in 2021-01-01T00:00:00Z2021 Mar2025-04-05T00:11:29.199Z2021-02-20T16:30:18ZS-EPMC76770413322143210.1016/j.cmi.2020.11.009