{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zhu Y"],"funding":["National Key R&amp;D Program of China","National Key R&D Program of China","Natural Science Foundation of Shandong Province","National Natural Science Foundation of China"],"pagination":["450"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7678311"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["16(1)"],"pubmed_abstract":["<h4>Background</h4>Interferon (IFN) regulatory factors (IRFs), as transcriptional regulatory factors, play important roles in regulating the expression of type I IFN and IFN- stimulated genes (ISGs) in innate immune responses. In addition, they participate in cell growth and development and regulate oncogenesis.<h4>Results</h4>In the present study, the cDNA sequence of IRF10 in common carp (Cyprinus carpio L.) was characterized (abbreviation, CcIRF10). The predicted protein sequence of CcIRF10 shared 52.7-89.2% identity with other teleost IRF10s and contained a DNA-binding domain (DBD), a nuclear localization signal (NLS) and an IRF-associated domain (IAD). Phylogenetic analysis showed that CcIRF10 had the closest relationship with IRF10 of Ctenopharyngodon idella. CcIRF10 transcripts were"],"journal":["BMC veterinary research"],"pubmed_title":["Identification of an IRF10 gene in common carp (Cyprinus carpio L.) and analysis of its function in the antiviral and antibacterial immune response."],"pmcid":["PMC7678311"],"funding_grant_id":["ZR2018BCE054","31972828","2018YFD0900302-8"],"pubmed_authors":["Yang G","Li H","Zhu Y","Liu R","Wang H","Chen X","Shan S","Zhao H"],"additional_accession":[]},"is_claimable":false,"name":"Identification of an IRF10 gene in common carp (Cyprinus carpio L.) and analysis of its function in the antiviral and antibacterial immune response.","description":"<h4>Background</h4>Interferon (IFN) regulatory factors (IRFs), as transcriptional regulatory factors, play important roles in regulating the expression of type I IFN and IFN- stimulated genes (ISGs) in innate immune responses. In addition, they participate in cell growth and development and regulate oncogenesis.<h4>Results</h4>In the present study, the cDNA sequence of IRF10 in common carp (Cyprinus carpio L.) was characterized (abbreviation, CcIRF10). The predicted protein sequence of CcIRF10 shared 52.7-89.2% identity with other teleost IRF10s and contained a DNA-binding domain (DBD), a nuclear localization signal (NLS) and an IRF-associated domain (IAD). Phylogenetic analysis showed that CcIRF10 had the closest relationship with IRF10 of Ctenopharyngodon idella. CcIRF10 transcripts were","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Nov","modification":"2026-04-07T17:11:44.866Z","creation":"2021-02-19T20:03:12Z"},"accession":"S-EPMC7678311","cross_references":{"pubmed":["33213475"],"doi":["10.1186/s12917-020-02674-z"]}}