biostudies-literatureZhu YNational Key R&amp;D Program of ChinaNational Key R&D Program of ChinaNatural Science Foundation of Shandong ProvinceNational Natural Science Foundation of China450https://www.ebi.ac.uk/biostudies/studies/S-EPMC7678311biostudies-literatureUnknown16(1)<h4>Background</h4>Interferon (IFN) regulatory factors (IRFs), as transcriptional regulatory factors, play important roles in regulating the expression of type I IFN and IFN- stimulated genes (ISGs) in innate immune responses. In addition, they participate in cell growth and development and regulate oncogenesis.<h4>Results</h4>In the present study, the cDNA sequence of IRF10 in common carp (Cyprinus carpio L.) was characterized (abbreviation, CcIRF10). The predicted protein sequence of CcIRF10 shared 52.7-89.2% identity with other teleost IRF10s and contained a DNA-binding domain (DBD), a nuclear localization signal (NLS) and an IRF-associated domain (IAD). Phylogenetic analysis showed that CcIRF10 had the closest relationship with IRF10 of Ctenopharyngodon idella. CcIRF10 transcripts wereBMC veterinary researchIdentification of an IRF10 gene in common carp (Cyprinus carpio L.) and analysis of its function in the antiviral and antibacterial immune response.PMC7678311ZR2018BCE054319728282018YFD0900302-8Yang GLi HZhu YLiu RWang HChen XShan SZhao HfalseIdentification of an IRF10 gene in common carp (Cyprinus carpio L.) and analysis of its function in the antiviral and antibacterial immune response.<h4>Background</h4>Interferon (IFN) regulatory factors (IRFs), as transcriptional regulatory factors, play important roles in regulating the expression of type I IFN and IFN- stimulated genes (ISGs) in innate immune responses. In addition, they participate in cell growth and development and regulate oncogenesis.<h4>Results</h4>In the present study, the cDNA sequence of IRF10 in common carp (Cyprinus carpio L.) was characterized (abbreviation, CcIRF10). The predicted protein sequence of CcIRF10 shared 52.7-89.2% identity with other teleost IRF10s and contained a DNA-binding domain (DBD), a nuclear localization signal (NLS) and an IRF-associated domain (IAD). Phylogenetic analysis showed that CcIRF10 had the closest relationship with IRF10 of Ctenopharyngodon idella. CcIRF10 transcripts were2020-01-01T00:00:00Z2020 Nov2026-04-07T17:11:44.866Z2021-02-19T20:03:12ZS-EPMC76783113321347510.1186/s12917-020-02674-z