{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Farrell KM"],"funding":["Wisconsin Alumni Research Foundation","NIDDK NIH HHS","National Institutes of Health","NIGMS NIH HHS","National Science Foundation","Office of the Vice Chancellor for Research and Graduate Education, University of Wisconsin-Madison"],"pagination":["33584-33602"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7679191"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["28(22)"],"pubmed_abstract":["The majority of 2D IR spectrometers operate at 1-10 kHz using Ti:Sapphire laser technology. We report a 2D IR spectrometer designed around Yb:KGW laser technology that operates shot-to-shot at 100 kHz. It includes a home-built OPA, a mid-IR pulse shaper, and custom-designed electronics with optional on-chip processing. We report a direct comparison between Yb:KGW and Ti:Sapphire based 2D IR spectrometers. Even though the mid-IR pulse energy is much lower for the Yb:KGW driven system, there is an 8x improvement in signal-to-noise over the 1 kHz Ti:Sapphire driven spectrometer to which it is compared. Experimental data is shown for sub-millimolar concentrations of amides. Advantages and disadvantages of the design are discussed, including thermal background that arises at high repetition rat"],"journal":["Optics express"],"pubmed_title":["Shot-to-shot 2D IR spectroscopy at 100 kHz using a Yb laser and custom-designed electronics."],"pmcid":["PMC7679191"],"funding_grant_id":["R01DK079895","R01 GM102387","DGE-1747503","R01 DK079895","R01GM102387","P30 DK020579"],"pubmed_authors":["Ostrander JS","Farrell KM","Jones AC","Dicke SS","Yakami BR","Zanni MT","Middleton CT","Hamm P"],"additional_accession":[]},"is_claimable":false,"name":"Shot-to-shot 2D IR spectroscopy at 100 kHz using a Yb laser and custom-designed electronics.","description":"The majority of 2D IR spectrometers operate at 1-10 kHz using Ti:Sapphire laser technology. We report a 2D IR spectrometer designed around Yb:KGW laser technology that operates shot-to-shot at 100 kHz. It includes a home-built OPA, a mid-IR pulse shaper, and custom-designed electronics with optional on-chip processing. We report a direct comparison between Yb:KGW and Ti:Sapphire based 2D IR spectrometers. Even though the mid-IR pulse energy is much lower for the Yb:KGW driven system, there is an 8x improvement in signal-to-noise over the 1 kHz Ti:Sapphire driven spectrometer to which it is compared. Experimental data is shown for sub-millimolar concentrations of amides. Advantages and disadvantages of the design are discussed, including thermal background that arises at high repetition rat","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Oct","modification":"2026-07-16T00:39:26.186Z","creation":"2026-07-09T10:26:31.041Z"},"accession":"S-EPMC7679191","cross_references":{"pubmed":["33115018"],"doi":["10.1364/OE.409360","10.1364/oe.409360"]}}