{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["10(1)"],"submitter":["Bodin A"],"funding":["Fédération francaise de cardiologie","and Association Universitaire de Recherche Cardiovasculaire d'Indre et Loire"],"pubmed_abstract":["Implantable cardioverter-defibrillators (ICD) are meant to fight life-threatening ventricular arrhythmias and reduce overall mortality. Ironically, life-saving shocks themselves have been shown to be independently associated with an increased mortality. We sought to identify myocardial changes at the protein level immediately after ICD electrical shocks using a proteomic approach. ICD were surgically implanted in 10 individuals of a healthy male sheep model: a control group (N = 5) without any shock delivery and a shock group (N = 5) with the delivery of 5 consecutive shocks at 41 J. Myocardial tissue samples were collected at the right-ventricle apex near to the lead coil and at the right ventricle basal free wall region. Global quantitative proteomics experiments on myocardial tissue sam"],"journal":["Scientific reports"],"pagination":["20252"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7679418"],"repository":["biostudies-literature"],"pubmed_title":["Acute pathophysiological myocardial changes following intra-cardiac electrical shocks using a proteomic approach in a sheep model."],"pmcid":["PMC7679418"],"pubmed_authors":["Combes-Soia L","Miquelestorena-Standley E","Bisson A","Labas V","Blasco H","Angoulvant D","Bodin A","Tomas D","Marcelo P","Baron C","Babuty D","Teixeira-Gomes AP","Clementy N"],"additional_accession":[]},"is_claimable":false,"name":"Acute pathophysiological myocardial changes following intra-cardiac electrical shocks using a proteomic approach in a sheep model.","description":"Implantable cardioverter-defibrillators (ICD) are meant to fight life-threatening ventricular arrhythmias and reduce overall mortality. Ironically, life-saving shocks themselves have been shown to be independently associated with an increased mortality. We sought to identify myocardial changes at the protein level immediately after ICD electrical shocks using a proteomic approach. ICD were surgically implanted in 10 individuals of a healthy male sheep model: a control group (N = 5) without any shock delivery and a shock group (N = 5) with the delivery of 5 consecutive shocks at 41 J. Myocardial tissue samples were collected at the right-ventricle apex near to the lead coil and at the right ventricle basal free wall region. Global quantitative proteomics experiments on myocardial tissue sam","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Nov","modification":"2025-04-19T14:55:40.397Z","creation":"2021-02-20T00:29:12Z"},"accession":"S-EPMC7679418","cross_references":{"pubmed":["33219330"],"doi":["10.1038/s41598-020-77346-x"]}}