biostudies-literatureUnknown10(1)Bodin AFédération francaise de cardiologieand Association Universitaire de Recherche Cardiovasculaire d'Indre et LoireImplantable cardioverter-defibrillators (ICD) are meant to fight life-threatening ventricular arrhythmias and reduce overall mortality. Ironically, life-saving shocks themselves have been shown to be independently associated with an increased mortality. We sought to identify myocardial changes at the protein level immediately after ICD electrical shocks using a proteomic approach. ICD were surgically implanted in 10 individuals of a healthy male sheep model: a control group (N = 5) without any shock delivery and a shock group (N = 5) with the delivery of 5 consecutive shocks at 41 J. Myocardial tissue samples were collected at the right-ventricle apex near to the lead coil and at the right ventricle basal free wall region. Global quantitative proteomics experiments on myocardial tissue samScientific reports20252https://www.ebi.ac.uk/biostudies/studies/S-EPMC7679418biostudies-literatureAcute pathophysiological myocardial changes following intra-cardiac electrical shocks using a proteomic approach in a sheep model.PMC7679418Combes-Soia LMiquelestorena-Standley EBisson ALabas VBlasco HAngoulvant DBodin ATomas DMarcelo PBaron CBabuty DTeixeira-Gomes APClementy NfalseAcute pathophysiological myocardial changes following intra-cardiac electrical shocks using a proteomic approach in a sheep model.Implantable cardioverter-defibrillators (ICD) are meant to fight life-threatening ventricular arrhythmias and reduce overall mortality. Ironically, life-saving shocks themselves have been shown to be independently associated with an increased mortality. We sought to identify myocardial changes at the protein level immediately after ICD electrical shocks using a proteomic approach. ICD were surgically implanted in 10 individuals of a healthy male sheep model: a control group (N = 5) without any shock delivery and a shock group (N = 5) with the delivery of 5 consecutive shocks at 41 J. Myocardial tissue samples were collected at the right-ventricle apex near to the lead coil and at the right ventricle basal free wall region. Global quantitative proteomics experiments on myocardial tissue sam2020-01-01T00:00:00Z2020 Nov2025-04-19T14:55:40.397Z2021-02-20T00:29:12ZS-EPMC76794183321933010.1038/s41598-020-77346-x