{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zemel BS"],"funding":["Children&apos;s Hospital of Philadelphia Research Institute","Children&apos;s Hospital of Philadelphia","NICHD NIH HHS","Translational Research Center","NCRR NIH HHS","National Institute of Child Health and Human Development"],"pagination":["115581"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7680379"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["141"],"pubmed_abstract":["<h4>Background</h4>Bone mineral content (BMC) and areal-bone mineral density (aBMD) measurements of the lumbar spine (LS) and whole body less head (WBLH) by dual energy X-ray absorptiometry (DXA) are recommended for bone health assessment in children. Intermachine differences were not considered previously in formulating these recommendations.<h4>Methodology</h4>DXA measurements of the LS, WBLH, total hip, femoral neck and distal 1/3 radius from the Bone Mineral Density in Childhood Study were examined. Healthy children, ages 6 to 16 years, from five clinical centers participated. The same spine, whole body, and femur phantoms were measured on each Center's DXA machine. Percentage of individuals with low BMC or aBMD (Z-score < -1.5) was determined. Clinical center differences were evaluate"],"journal":["Bone"],"pubmed_title":["Intermachine differences in DXA measurements vary by skeletal site, and impact the assessment of low bone density in children."],"pmcid":["PMC7680379"],"funding_grant_id":["N01HD13330","N01HD13333","-3329","N01HD13332","N01HD13331","N01HD13329","5-MO1-RR-000240","N01HD13328","UL1 RR-026314","NO1-HD-1-3228","UL1 RR026314","-3330","UL1 RR024134","-3331","-3332","-3333","M01 RR000240"],"pubmed_authors":["Shepherd J","Kelly A","Lappe J","Gilsanz V","Wasserman H","Zemel BS","Winer KK","Fan B","Oberfield S","Kalkwarf HJ"],"additional_accession":[]},"is_claimable":false,"name":"Intermachine differences in DXA measurements vary by skeletal site, and impact the assessment of low bone density in children.","description":"<h4>Background</h4>Bone mineral content (BMC) and areal-bone mineral density (aBMD) measurements of the lumbar spine (LS) and whole body less head (WBLH) by dual energy X-ray absorptiometry (DXA) are recommended for bone health assessment in children. Intermachine differences were not considered previously in formulating these recommendations.<h4>Methodology</h4>DXA measurements of the LS, WBLH, total hip, femoral neck and distal 1/3 radius from the Bone Mineral Density in Childhood Study were examined. Healthy children, ages 6 to 16 years, from five clinical centers participated. The same spine, whole body, and femur phantoms were measured on each Center's DXA machine. Percentage of individuals with low BMC or aBMD (Z-score < -1.5) was determined. Clinical center differences were evaluate","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Dec","modification":"2025-04-21T21:40:28.594Z","creation":"2022-02-11T13:15:15.693Z"},"accession":"S-EPMC7680379","cross_references":{"pubmed":["32795677"],"doi":["10.1016/j.bone.2020.115581"]}}