biostudies-literatureZemel BSChildren&apos;s Hospital of Philadelphia Research InstituteChildren&apos;s Hospital of PhiladelphiaNICHD NIH HHSTranslational Research CenterNCRR NIH HHSNational Institute of Child Health and Human Development115581https://www.ebi.ac.uk/biostudies/studies/S-EPMC7680379biostudies-literatureUnknown141<h4>Background</h4>Bone mineral content (BMC) and areal-bone mineral density (aBMD) measurements of the lumbar spine (LS) and whole body less head (WBLH) by dual energy X-ray absorptiometry (DXA) are recommended for bone health assessment in children. Intermachine differences were not considered previously in formulating these recommendations.<h4>Methodology</h4>DXA measurements of the LS, WBLH, total hip, femoral neck and distal 1/3 radius from the Bone Mineral Density in Childhood Study were examined. Healthy children, ages 6 to 16 years, from five clinical centers participated. The same spine, whole body, and femur phantoms were measured on each Center's DXA machine. Percentage of individuals with low BMC or aBMD (Z-score < -1.5) was determined. Clinical center differences were evaluateBoneIntermachine differences in DXA measurements vary by skeletal site, and impact the assessment of low bone density in children.PMC7680379N01HD13330N01HD13333-3329N01HD13332N01HD13331N01HD133295-MO1-RR-000240N01HD13328UL1 RR-026314NO1-HD-1-3228UL1 RR026314-3330UL1 RR024134-3331-3332-3333M01 RR000240Shepherd JKelly ALappe JGilsanz VWasserman HZemel BSWiner KKFan BOberfield SKalkwarf HJfalseIntermachine differences in DXA measurements vary by skeletal site, and impact the assessment of low bone density in children.<h4>Background</h4>Bone mineral content (BMC) and areal-bone mineral density (aBMD) measurements of the lumbar spine (LS) and whole body less head (WBLH) by dual energy X-ray absorptiometry (DXA) are recommended for bone health assessment in children. Intermachine differences were not considered previously in formulating these recommendations.<h4>Methodology</h4>DXA measurements of the LS, WBLH, total hip, femoral neck and distal 1/3 radius from the Bone Mineral Density in Childhood Study were examined. Healthy children, ages 6 to 16 years, from five clinical centers participated. The same spine, whole body, and femur phantoms were measured on each Center's DXA machine. Percentage of individuals with low BMC or aBMD (Z-score < -1.5) was determined. Clinical center differences were evaluate2020-01-01T00:00:00Z2020 Dec2025-04-21T21:40:28.594Z2022-02-11T13:15:15.693ZS-EPMC76803793279567710.1016/j.bone.2020.115581