{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ford AL"],"funding":["NCATS NIH HHS","NIAID NIH HHS","NHLBI NIH HHS","NIAMS NIH HHS"],"pagination":["e1918-e1931"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7682842"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["95(14)"],"pubmed_abstract":["<h4>Objective</h4>To characterize lesion evolution and neurodegeneration in retinal vasculopathy with cerebral leukoencephalopathy and systemic manifestations (RVCL-S) using multimodal MRI.<h4>Methods</h4>We prospectively performed MRI and cognitive testing in RVCL-S and healthy control cohorts. Gray and white matter volume and disruption of white matter microstructure were quantified. Asymmetric spin echo acquisition permitted voxel-wise oxygen extraction fraction (OEF) calculation as an in vivo marker of microvascular ischemia. The RVCL-S cohort was included in a longitudinal analysis of lesion subtypes in which hyperintense lesions on fluid-attenuated inversion recovery (FLAIR), T1-postgadolinium, and diffusion-weighted imaging were delineated and quantified volumetrically.<h4>Results</"],"journal":["Neurology"],"pubmed_title":["Lesion evolution and neurodegeneration in RVCL-S: A monogenic microvasculopathy."],"pmcid":["PMC7682842"],"funding_grant_id":["R01 AI143982","R01 HL129241","UL1 TR002345","K08 AR070918","UL1 TR000448"],"pubmed_authors":["Balasetti V","Miner JJ","Ford AL","Chin VW","Hassenstab J","Binkley MM","An H","Fellah S","Jen JC","Bodin AM","Liszewski MK","Bogacki M","Lin D","Grand MG","Atkinson JP","Kang P","Chen Y","Lee JM","Taiwo Y","Hourcade D"],"additional_accession":[]},"is_claimable":false,"name":"Lesion evolution and neurodegeneration in RVCL-S: A monogenic microvasculopathy.","description":"<h4>Objective</h4>To characterize lesion evolution and neurodegeneration in retinal vasculopathy with cerebral leukoencephalopathy and systemic manifestations (RVCL-S) using multimodal MRI.<h4>Methods</h4>We prospectively performed MRI and cognitive testing in RVCL-S and healthy control cohorts. Gray and white matter volume and disruption of white matter microstructure were quantified. Asymmetric spin echo acquisition permitted voxel-wise oxygen extraction fraction (OEF) calculation as an in vivo marker of microvascular ischemia. The RVCL-S cohort was included in a longitudinal analysis of lesion subtypes in which hyperintense lesions on fluid-attenuated inversion recovery (FLAIR), T1-postgadolinium, and diffusion-weighted imaging were delineated and quantified volumetrically.<h4>Results</","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Oct","modification":"2025-04-04T10:55:28.031Z","creation":"2021-02-21T06:30:25Z"},"accession":"S-EPMC7682842","cross_references":{"pubmed":["32887784"],"doi":["10.1212/WNL.0000000000010659"]}}