biostudies-literatureSanchez JHorizon 2020 Framework ProgrammeNIAID NIH HHSSeventh Framework Programme586124https://www.ebi.ac.uk/biostudies/studies/S-EPMC7683801biostudies-literatureUnknown11<h4>Background</h4>Our previous work has demonstrated the benefits of transcutaneous immunization in targeting Langerhans cells and preferentially inducing CD8 T-cell responses.<h4>Methods</h4>In this randomized phase Ib clinical trial including 20 HIV uninfected volunteers, we compared the safety and immunogenicity of the MVA recombinant vaccine expressing HIV-B antigen (MVA-B) by transcutaneous and intramuscular routes. We hypothesized that the quality of innate and adaptive immunity differs according to the route of immunization and explored the quality of the vector vaccine-induced immune responses. We also investigated the early blood transcriptome and serum cytokine levels to identify innate events correlated with the strength and quality of adaptive immunity.<h4>Results</h4>We demonFrontiers in immunologyImmune Profiles Identification by Vaccinomics After MVA Immunization in Randomized Clinical Study.PMC7683801P01 AI131568Bonduelle OEsteban MGomez CEPerez SCombadiere BSoria AVogt ASanchez JLlano AMothe BLama JRFernandez-Maldonado MGarcia FGoncalves EGonzales PFernandez MAde Bernard SPedruzzi EBrander CCedeno SNourikyan JGanoza CfalseImmune Profiles Identification by Vaccinomics After MVA Immunization in Randomized Clinical Study.<h4>Background</h4>Our previous work has demonstrated the benefits of transcutaneous immunization in targeting Langerhans cells and preferentially inducing CD8 T-cell responses.<h4>Methods</h4>In this randomized phase Ib clinical trial including 20 HIV uninfected volunteers, we compared the safety and immunogenicity of the MVA recombinant vaccine expressing HIV-B antigen (MVA-B) by transcutaneous and intramuscular routes. We hypothesized that the quality of innate and adaptive immunity differs according to the route of immunization and explored the quality of the vector vaccine-induced immune responses. We also investigated the early blood transcriptome and serum cytokine levels to identify innate events correlated with the strength and quality of adaptive immunity.<h4>Results</h4>We demon2020-01-01T00:00:00Z20202026-04-08T02:59:46.276Z2021-02-20T00:56:29ZS-EPMC76838013324431610.3389/fimmu.2020.586124