{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Song P"],"funding":["National Natural Science Foundation of China"],"pagination":["6069-6082"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7684604"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["8(11)"],"pubmed_abstract":["<i>Fructus Rosae Roxburghii</i> (FRR) as a dietary supplement is considered to possess anti-atherosclerosis (AS), and hyperlipidemia (HLP) is material basis for AS formation, so the effects and molecular mechanism of FRR on diet-induced hyperlipidemic mice were explored. In Diet IV2 group, hepatic steatosis was significantly relieved; meanwhile, TC, TG, LDL-C, HDL-C, and ASI in serum were regulated to control level. Thirty-seven DCEG in Diet I, Diet II, and Diet IV2 groups were obtained by RNA-seq analysis. Relative mRNA levels were further determined by qRT-PCR, of which 28 genes were matched with those detected by RNA-seq. Ten DCEP were verified by targeted quantitative proteomic analysis, but expressive patterns of only six proteins were correlated with qRT-PCR data. These DCEG and DCEP"],"journal":["Food science & nutrition"],"pubmed_title":["Juice from <i>Fructus Rosae Roxburghii</i> normalizes blood lipids in mice with diet-induced hyperlipidemia*<sup>†</sup>."],"pmcid":["PMC7684604"],"funding_grant_id":["31760325","U1812403‐4‐4","81760725"],"pubmed_authors":["Song P","Shen X"],"additional_accession":[]},"is_claimable":false,"name":"Juice from <i>Fructus Rosae Roxburghii</i> normalizes blood lipids in mice with diet-induced hyperlipidemia*<sup>†</sup>.","description":"<i>Fructus Rosae Roxburghii</i> (FRR) as a dietary supplement is considered to possess anti-atherosclerosis (AS), and hyperlipidemia (HLP) is material basis for AS formation, so the effects and molecular mechanism of FRR on diet-induced hyperlipidemic mice were explored. In Diet IV2 group, hepatic steatosis was significantly relieved; meanwhile, TC, TG, LDL-C, HDL-C, and ASI in serum were regulated to control level. Thirty-seven DCEG in Diet I, Diet II, and Diet IV2 groups were obtained by RNA-seq analysis. Relative mRNA levels were further determined by qRT-PCR, of which 28 genes were matched with those detected by RNA-seq. Ten DCEP were verified by targeted quantitative proteomic analysis, but expressive patterns of only six proteins were correlated with qRT-PCR data. These DCEG and DCEP","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Nov","modification":"2025-04-04T22:36:44.457Z","creation":"2021-02-20T10:38:19Z"},"accession":"S-EPMC7684604","cross_references":{"pubmed":["33282259"],"doi":["10.1002/fsn3.1897"]}}