{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Petropoulou PI"],"funding":["Roche-Chugai","NCATS NIH HHS","NIDDK NIH HHS","NIA NIH HHS","NHLBI NIH HHS","National Institutes of Health","National Institute of Food and Agriculture","NIH HHS","National Institute on Aging"],"pagination":["e58949"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7685704"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["9"],"pubmed_abstract":["In the mouse, the osteoblast-derived hormone Lipocalin-2 (LCN2) suppresses food intake and acts as a satiety signal. We show here that meal challenges increase serum LCN2 levels in persons with normal or overweight, but not in individuals with obesity. Postprandial LCN2 serum levels correlate inversely with hunger sensation in challenged subjects. We further show through brain PET scans of monkeys injected with radiolabeled recombinant human LCN2 (rh-LCN2) and autoradiography in baboon, macaque, and human brain sections, that LCN2 crosses the blood-brain barrier and localizes to the hypothalamus in primates. In addition, daily treatment of lean monkeys with rh-LCN2 decreases food intake by 21%, without overt side effects. These studies demonstrate the biology of LCN2 as a satiety factor an"],"journal":["eLife"],"pubmed_title":["Lipocalin-2 is an anorexigenic signal in primates."],"pmcid":["PMC7685704"],"funding_grant_id":["UL1 TR000040","UL1TR001420","UL1 TR001873","P40OD010965","UL1 TR001420","UL1TR001873","P30DK26687-30","T32HL120826","P30 DK063608","P01AG032959","P30DK063608","UL1TR000040","NJAES - 0153866","R01 DK067561","P40 OD010965","P01 AG032959","P30 DK026687","RO1DK067561","T32 HL120826"],"pubmed_authors":["Laferrere B","Underwood MD","Kassir S","Hao L","Confavreux CB","Kim J","Bahna F","Rubin M","Bisikirska B","Shikhel S","Mosialou I","May CM","Zanderigo F","Jorgensen MJ","Mintz A","Mann JJ","Shapiro L","Panitsas K","Luo N","Soligapuram Sai KK","Bakalian M","Carberry P","Petropoulou PI","Shapses S","Kousteni S","Simpson N"],"additional_accession":[]},"is_claimable":false,"name":"Lipocalin-2 is an anorexigenic signal in primates.","description":"In the mouse, the osteoblast-derived hormone Lipocalin-2 (LCN2) suppresses food intake and acts as a satiety signal. We show here that meal challenges increase serum LCN2 levels in persons with normal or overweight, but not in individuals with obesity. Postprandial LCN2 serum levels correlate inversely with hunger sensation in challenged subjects. We further show through brain PET scans of monkeys injected with radiolabeled recombinant human LCN2 (rh-LCN2) and autoradiography in baboon, macaque, and human brain sections, that LCN2 crosses the blood-brain barrier and localizes to the hypothalamus in primates. In addition, daily treatment of lean monkeys with rh-LCN2 decreases food intake by 21%, without overt side effects. These studies demonstrate the biology of LCN2 as a satiety factor an","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Nov","modification":"2026-04-16T23:14:07.181Z","creation":"2021-02-20T02:49:19Z"},"accession":"S-EPMC7685704","cross_references":{"pubmed":["33231171"],"doi":["10.7554/eLife.58949"]}}