{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ganesan R"],"funding":["American Heart Association","NHLBI NIH HHS","National Institutes of Health","NIGMS NIH HHS"],"pagination":["15888-15906"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7686130"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["34(12)"],"pubmed_abstract":["A successful acute inflammatory response results in the elimination of infectious agents by neutrophils and monocytes, followed by resolution and repair through tissue-resident and recruited macrophages. Resolvins (D-series and E-series) are pro-resolving lipid mediators involved in resolution and tissue repair, whose intracellular signaling remains of interest. Here, we report that D-series resolvins (RvD1- RvD5) activate phospholipase D (PLD), a ubiquitously expressed membrane lipase enzyme activity in modulating phagocyte functions. The mechanism for PLD-mediated actions of Resolvin-D5 (RvD5) in polarizing macrophages (M1-like toward M2-like) was found to be two-pronged: (a) RvD5 inhibits post-transcriptional modifications, by miRs and 3'exonucleases that process PLD2 mRNA, thus increas"],"journal":["FASEB journal : official publication of the Federation of American Societies for Experimental Biology"],"pubmed_title":["D-series Resolvins activate Phospholipase D in phagocytes during inflammation and resolution."],"pmcid":["PMC7686130"],"funding_grant_id":["R01 HL056653","P01 GM095467","13GRNT17230097","R29 HL056653","P01GM095467","HL056653‐14"],"pubmed_authors":["Henkels KM","Ganesan R","Cheemarla NR","Gomez-Cambronero J","Serhan CN","De La Rosa X","Libreros S","Shah K"],"additional_accession":[]},"is_claimable":false,"name":"D-series Resolvins activate Phospholipase D in phagocytes during inflammation and resolution.","description":"A successful acute inflammatory response results in the elimination of infectious agents by neutrophils and monocytes, followed by resolution and repair through tissue-resident and recruited macrophages. Resolvins (D-series and E-series) are pro-resolving lipid mediators involved in resolution and tissue repair, whose intracellular signaling remains of interest. Here, we report that D-series resolvins (RvD1- RvD5) activate phospholipase D (PLD), a ubiquitously expressed membrane lipase enzyme activity in modulating phagocyte functions. The mechanism for PLD-mediated actions of Resolvin-D5 (RvD5) in polarizing macrophages (M1-like toward M2-like) was found to be two-pronged: (a) RvD5 inhibits post-transcriptional modifications, by miRs and 3'exonucleases that process PLD2 mRNA, thus increas","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Dec","modification":"2025-04-21T21:42:42.429Z","creation":"2022-02-11T13:14:40.918Z"},"accession":"S-EPMC7686130","cross_references":{"pubmed":["33047359"],"doi":["10.1096/fj.201903025RR","10.1096/fj.201903025rr"]}}