{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Bueno DF"],"funding":["PROADI-SUS"],"pagination":["501"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7687766"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["11(1)"],"pubmed_abstract":["<h4>Background</h4>Bone reconstruction in congenital craniofacial differences, which affect about 2-3% of newborns, has long been the focus of intensive research in the field of bone tissue engineering. The possibility of using mesenchymal stromal cells in regenerative medicine protocols has opened a new field of investigation aimed at finding optimal sources of multipotent cells that can be isolated via non-invasive procedures. In this study, we analyzed whether levator veli palatini muscle fragments, which can be readily obtained in non-invasive manner during palatoplasty in cleft palate patients, represent a novel source of MSCs with osteogenic potential.<h4>Methods</h4>We obtained levator veli palatini muscle fragments (3-5 mm<sup>3</sup>), during surgical repair of cleft palate in 5 u"],"journal":["Stem cell research & therapy"],"pubmed_title":["Human levator veli palatini muscle: a novel source of mesenchymal stromal cells for use in the rehabilitation of patients with congenital craniofacial malformations."],"pmcid":["PMC7687766"],"funding_grant_id":["25000.009809/2018-65"],"pubmed_authors":["Rocha DL","Shibuya Y","Kabayashi GS","Tanikawa DYS","Raposo-Amaral CE","ZuK PA","Ferreira JRM","Passos-Bueno MR","Hokugo A","Jarrahy R","Bueno DF","Pinheiro CCG"],"additional_accession":[]},"is_claimable":false,"name":"Human levator veli palatini muscle: a novel source of mesenchymal stromal cells for use in the rehabilitation of patients with congenital craniofacial malformations.","description":"<h4>Background</h4>Bone reconstruction in congenital craniofacial differences, which affect about 2-3% of newborns, has long been the focus of intensive research in the field of bone tissue engineering. The possibility of using mesenchymal stromal cells in regenerative medicine protocols has opened a new field of investigation aimed at finding optimal sources of multipotent cells that can be isolated via non-invasive procedures. In this study, we analyzed whether levator veli palatini muscle fragments, which can be readily obtained in non-invasive manner during palatoplasty in cleft palate patients, represent a novel source of MSCs with osteogenic potential.<h4>Methods</h4>We obtained levator veli palatini muscle fragments (3-5 mm<sup>3</sup>), during surgical repair of cleft palate in 5 u","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Nov","modification":"2026-04-30T06:23:03.217Z","creation":"2021-02-20T03:03:52Z"},"accession":"S-EPMC7687766","cross_references":{"pubmed":["33239080"],"doi":["10.1186/s13287-020-02017-7"]}}