{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["10"],"submitter":["Bewarder M"],"pubmed_abstract":["Recently, neurabin-I and SAMD14 have been described as the autoantigenic target of approximately 66% of B-cell receptors (BCRs) of primary central nervous system lymphomas (PCNSL). Neurabin-I and SAMD14 share a highly homologous SAM domain that becomes immunogenic after atypical hyper-N-glycosylation (SAMD14 at ASN339 and neurabin-I at ASN1277). This post-translational modification of neurabin-I and SAMD14 seems to lead to a chronic immune reaction with B-cell receptor activation contributing to lymphoma genesis of PCNSLs. The selective tropism of PCNSL to the CNS corresponds well to the neurabin-I and SAMD14 protein expression pattern. When conjugated to Pseudomonas Exotoxin A (ETA´), the PCNSL reactive epitope exerts cytotoxic effects on lymphoma cells expressing a SAMD14/neurabin-I reac"],"journal":["Frontiers in oncology"],"pagination":["580364"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7689012"],"repository":["biostudies-literature"],"pubmed_title":["Integration of the B-Cell Receptor Antigen Neurabin-I/SAMD14 Into an Antibody Format as New Therapeutic Approach for the Treatment of Primary CNS Lymphoma."],"pmcid":["PMC7689012"],"pubmed_authors":["Pfreundschuh M","Hoth M","Bewarder M","Moelle C","Preuss KD","Neumann F","Kiefer M","Regitz E","Kaddu-Mulindwa D","Christofyllakis K","Thurner L","Stilgenbauer S","Fadle N","Goerens L"],"additional_accession":[]},"is_claimable":false,"name":"Integration of the B-Cell Receptor Antigen Neurabin-I/SAMD14 Into an Antibody Format as New Therapeutic Approach for the Treatment of Primary CNS Lymphoma.","description":"Recently, neurabin-I and SAMD14 have been described as the autoantigenic target of approximately 66% of B-cell receptors (BCRs) of primary central nervous system lymphomas (PCNSL). Neurabin-I and SAMD14 share a highly homologous SAM domain that becomes immunogenic after atypical hyper-N-glycosylation (SAMD14 at ASN339 and neurabin-I at ASN1277). This post-translational modification of neurabin-I and SAMD14 seems to lead to a chronic immune reaction with B-cell receptor activation contributing to lymphoma genesis of PCNSLs. The selective tropism of PCNSL to the CNS corresponds well to the neurabin-I and SAMD14 protein expression pattern. When conjugated to Pseudomonas Exotoxin A (ETA´), the PCNSL reactive epitope exerts cytotoxic effects on lymphoma cells expressing a SAMD14/neurabin-I reac","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020","modification":"2025-04-25T20:43:07.98Z","creation":"2021-02-20T10:07:24Z"},"accession":"S-EPMC7689012","cross_references":{"pubmed":["33282736"],"doi":["10.3389/fonc.2020.580364"]}}