{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Koh J"],"funding":["Korean Government","NRF (National Research Foundation of Korea)"],"pagination":["1810-1819"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7689686"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["50(11)"],"pubmed_abstract":["The major suppressive immune cells in tumor sites are myeloid derived suppressor cells (MDSCs), tumor-associated macrophages (TAMs), and Treg cells, and the major roles of these suppressive immune cells include hindering T-cell activities and supporting tumor progression and survival. In this study, we analyzed the pattern of circulating MDSC subtypes in patients with non-small cell lung cancer (NSCLC) whether those suppressive immune cells hinder T-cell activities leading to poor clinical outcomes. First, we verified PMN-MDSCs, monocytic-MDSCs (M-MDSCs), and Treg cells increased according to the stages of NSCLC, and MDSCs effectively suppressed T-cell activities and induced T-cell exhaustion. The analysis of NSCLC patients treated with anti-PD-1 immunotherapy demonstrated that low PMN-MDS"],"journal":["European journal of immunology"],"pubmed_title":["MDSC subtypes and CD39 expression on CD8<sup>+</sup> T cells predict the efficacy of anti-PD-1 immunotherapy in patients with advanced NSCLC."],"pmcid":["PMC7689686"],"funding_grant_id":["NRF-2017M3A9G5060259","NRF-2017H1A2A1044327"],"pubmed_authors":["Ahn MJ","Kim MS","Kim B","Park K","Lee SH","Hur JY","Lee KY","Bae YH","Lee YC","Sun JM","Ahn JS","Ku BM","Cho HJ","Koh J","Kim Y"],"additional_accession":[]},"is_claimable":false,"name":"MDSC subtypes and CD39 expression on CD8<sup>+</sup> T cells predict the efficacy of anti-PD-1 immunotherapy in patients with advanced NSCLC.","description":"The major suppressive immune cells in tumor sites are myeloid derived suppressor cells (MDSCs), tumor-associated macrophages (TAMs), and Treg cells, and the major roles of these suppressive immune cells include hindering T-cell activities and supporting tumor progression and survival. In this study, we analyzed the pattern of circulating MDSC subtypes in patients with non-small cell lung cancer (NSCLC) whether those suppressive immune cells hinder T-cell activities leading to poor clinical outcomes. First, we verified PMN-MDSCs, monocytic-MDSCs (M-MDSCs), and Treg cells increased according to the stages of NSCLC, and MDSCs effectively suppressed T-cell activities and induced T-cell exhaustion. The analysis of NSCLC patients treated with anti-PD-1 immunotherapy demonstrated that low PMN-MDS","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Nov","modification":"2026-05-03T05:02:02.484Z","creation":"2021-02-20T03:04:50Z"},"accession":"S-EPMC7689686","cross_references":{"pubmed":["32510574"],"doi":["10.1002/eji.202048534"]}}