biostudies-literatureKoh JKorean GovernmentNRF (National Research Foundation of Korea)1810-1819https://www.ebi.ac.uk/biostudies/studies/S-EPMC7689686biostudies-literatureUnknown50(11)The major suppressive immune cells in tumor sites are myeloid derived suppressor cells (MDSCs), tumor-associated macrophages (TAMs), and Treg cells, and the major roles of these suppressive immune cells include hindering T-cell activities and supporting tumor progression and survival. In this study, we analyzed the pattern of circulating MDSC subtypes in patients with non-small cell lung cancer (NSCLC) whether those suppressive immune cells hinder T-cell activities leading to poor clinical outcomes. First, we verified PMN-MDSCs, monocytic-MDSCs (M-MDSCs), and Treg cells increased according to the stages of NSCLC, and MDSCs effectively suppressed T-cell activities and induced T-cell exhaustion. The analysis of NSCLC patients treated with anti-PD-1 immunotherapy demonstrated that low PMN-MDSEuropean journal of immunologyMDSC subtypes and CD39 expression on CD8⁺ T cells predict the efficacy of anti-PD-1 immunotherapy in patients with advanced NSCLC.PMC7689686NRF-2017M3A9G5060259NRF-2017H1A2A1044327Ahn MJKim MSKim BPark KLee SHHur JYLee KYBae YHLee YCSun JMAhn JSKu BMCho HJKoh JKim YfalseMDSC subtypes and CD39 expression on CD8⁺ T cells predict the efficacy of anti-PD-1 immunotherapy in patients with advanced NSCLC.The major suppressive immune cells in tumor sites are myeloid derived suppressor cells (MDSCs), tumor-associated macrophages (TAMs), and Treg cells, and the major roles of these suppressive immune cells include hindering T-cell activities and supporting tumor progression and survival. In this study, we analyzed the pattern of circulating MDSC subtypes in patients with non-small cell lung cancer (NSCLC) whether those suppressive immune cells hinder T-cell activities leading to poor clinical outcomes. First, we verified PMN-MDSCs, monocytic-MDSCs (M-MDSCs), and Treg cells increased according to the stages of NSCLC, and MDSCs effectively suppressed T-cell activities and induced T-cell exhaustion. The analysis of NSCLC patients treated with anti-PD-1 immunotherapy demonstrated that low PMN-MDS2020-01-01T00:00:00Z2020 Nov2026-05-03T05:02:02.484Z2021-02-20T03:04:50ZS-EPMC76896863251057410.1002/eji.202048534