{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Sun GY"],"funding":["Beijing Clinical Application Research Project","National Key Projects of Research and Development of China","National Natural Science Foundation of China"],"pagination":["1155"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7691055"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["20(1)"],"pubmed_abstract":["Background
To compare the survival outcomes between breast-conserving surgery (BCS) and modified radical mastectomy (MRM), and to investigate the role of radiotherapy (RT) in patients with pT1-2N1M0 breast cancer.Methods
A total of 4262 women with T1-2N1M0 breast cancer treated at two institutions were retrospectively reviewed. A total of 3858 patients underwent MRM, and 832 (21.6%) of them received postoperative RT (MRM + RT). A total of 404 patients received BCS plus postoperative RT (BCS + RT). All patients received axillary lymph node dissection, while 3.8% of them had upfront sentinel node biopsy. The association of survival outcomes with different surgical modalities (BCS vs. MRM) and the role of RT were evaluated using multivariable proportional hazards regression an"],"journal":["BMC cancer"],"pubmed_title":["Radiotherapy plays an important role in improving the survival outcome in patients with T1-2N1M0 breast cancer - a joint analysis of 4262 real world cases from two institutions."],"pmcid":["PMC7691055"],"funding_grant_id":["81972860","2016YFC0904600","Z171100001017116"],"pubmed_authors":["Jing H","Fang H","Sun GY","Chen SY","Song YW","Qi SN","Zhang JH","Zhao XR","Wang JY","Chen B","Li N","Zhang YJ","Ren H","Liu YP","Yang Y","Lu NN","Wang SL","Jin J","Li YX","Wen G","Tang Y"],"additional_accession":[]},"is_claimable":false,"name":"Radiotherapy plays an important role in improving the survival outcome in patients with T1-2N1M0 breast cancer - a joint analysis of 4262 real world cases from two institutions.","description":"Background
To compare the survival outcomes between breast-conserving surgery (BCS) and modified radical mastectomy (MRM), and to investigate the role of radiotherapy (RT) in patients with pT1-2N1M0 breast cancer.Methods
A total of 4262 women with T1-2N1M0 breast cancer treated at two institutions were retrospectively reviewed. A total of 3858 patients underwent MRM, and 832 (21.6%) of them received postoperative RT (MRM + RT). A total of 404 patients received BCS plus postoperative RT (BCS + RT). All patients received axillary lymph node dissection, while 3.8% of them had upfront sentinel node biopsy. The association of survival outcomes with different surgical modalities (BCS vs. MRM) and the role of RT were evaluated using multivariable proportional hazards regression an","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Nov","modification":"2025-04-22T18:21:33.621Z","creation":"2025-04-06T02:27:09.623Z"},"accession":"S-EPMC7691055","cross_references":{"pubmed":["33243177"],"doi":["10.1186/s12885-020-07646-y"]}}