biostudies-literatureZhang JWenzhou Public Welfare Science and Technology ProgramProject of Zhejiang Province Science Research Foundation of Traditional Chinese Medicine367https://www.ebi.ac.uk/biostudies/studies/S-EPMC7691060biostudies-literatureUnknown20(1)<h4>Background</h4>This study aimed to investigate the mechanism of action of Panax notoginoside (PNS) against lung cancer and inhibition of lung cancer cell proliferation by the drug at different concentrations in a mouse model, considering the cathepsin B (CTSB) gene as a target.<h4>Methods</h4>The mice were randomly assigned into the following five groups: normal control, tumor-bearing, low-dose Panax notoginoside (TSPN), medium-dose TSPN, and high-dose TSPN. All mice were treated with physiological saline or TSPN at different concentrations for 28 days consecutively by gavage. The tumor size was measured, the tumor growth was observed, and the survival curve was drawn. At different time points, the expression of the CTSB gene was detected using quantitative fluorescent polymerase chainBMC complementary medicine and therapiesMechanism of action of Panax notoginoside against lung cancer in mice based on response to CTSB gene.PMC76910602016ZA178y20170170Ma BZhang JHuang ZJin SZhou BZhu WShao QfalseMechanism of action of Panax notoginoside against lung cancer in mice based on response to CTSB gene.<h4>Background</h4>This study aimed to investigate the mechanism of action of Panax notoginoside (PNS) against lung cancer and inhibition of lung cancer cell proliferation by the drug at different concentrations in a mouse model, considering the cathepsin B (CTSB) gene as a target.<h4>Methods</h4>The mice were randomly assigned into the following five groups: normal control, tumor-bearing, low-dose Panax notoginoside (TSPN), medium-dose TSPN, and high-dose TSPN. All mice were treated with physiological saline or TSPN at different concentrations for 28 days consecutively by gavage. The tumor size was measured, the tumor growth was observed, and the survival curve was drawn. At different time points, the expression of the CTSB gene was detected using quantitative fluorescent polymerase chain2020-01-01T00:00:00Z2020 Nov2025-04-22T18:20:29.782Z2025-04-06T02:26:48.917ZS-EPMC76910603323895910.1186/s12906-020-03159-0