{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Nishiyama H"],"funding":["JSPS KAKENHI","NIDDK NIH HHS","Scientific Research on Innovative Areas from the Ministry of Education, Culture, Science, Sports and Technology (MEXT) of Japan"],"pagination":["E1663"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7692956"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["8(11)"],"pubmed_abstract":["The aim of this study was to elucidate the ecological structure of the human gut temperate bacteriophage community and its role in inflammatory bowel disease (IBD). Temperate bacteriophages make up a large proportion of the human gut microbiota and are likely to play a role in IBD pathogenesis. However, many of these bacteriophages await characterization in reference databases. Therefore, we conducted a large-scale reconstruction of temperate bacteriophage and bacterial genomes from the whole-metagenome sequence data generated by the IBD Multi'omics Database project. By associating phages with their hosts via genome comparisons, we found that temperate bacteriophages infect a phylogenetically wide range of bacteria. The majority of variance in bacteriophage community composition was explai"],"journal":["Microorganisms"],"pubmed_title":["Ecological Structuring of Temperate Bacteriophages in the Inflammatory Bowel Disease-Affected Gut."],"pmcid":["PMC7692956"],"funding_grant_id":["16H06429","16H06437","U54 DK102557","19J14228","16K21723"],"pubmed_authors":["Blanc-Mathieu R","Ogata H","Nishiyama H","Endo H"],"additional_accession":[]},"is_claimable":false,"name":"Ecological Structuring of Temperate Bacteriophages in the Inflammatory Bowel Disease-Affected Gut.","description":"The aim of this study was to elucidate the ecological structure of the human gut temperate bacteriophage community and its role in inflammatory bowel disease (IBD). Temperate bacteriophages make up a large proportion of the human gut microbiota and are likely to play a role in IBD pathogenesis. However, many of these bacteriophages await characterization in reference databases. Therefore, we conducted a large-scale reconstruction of temperate bacteriophage and bacterial genomes from the whole-metagenome sequence data generated by the IBD Multi'omics Database project. By associating phages with their hosts via genome comparisons, we found that temperate bacteriophages infect a phylogenetically wide range of bacteria. The majority of variance in bacteriophage community composition was explai","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Oct","modification":"2026-04-08T00:35:40.622Z","creation":"2021-02-20T00:55:43Z"},"accession":"S-EPMC7692956","cross_references":{"pubmed":["33121006"],"doi":["10.3390/microorganisms8111663"]}}