biostudies-literatureNishiyama HJSPS KAKENHINIDDK NIH HHSScientific Research on Innovative Areas from the Ministry of Education, Culture, Science, Sports and Technology (MEXT) of JapanE1663https://www.ebi.ac.uk/biostudies/studies/S-EPMC7692956biostudies-literatureUnknown8(11)The aim of this study was to elucidate the ecological structure of the human gut temperate bacteriophage community and its role in inflammatory bowel disease (IBD). Temperate bacteriophages make up a large proportion of the human gut microbiota and are likely to play a role in IBD pathogenesis. However, many of these bacteriophages await characterization in reference databases. Therefore, we conducted a large-scale reconstruction of temperate bacteriophage and bacterial genomes from the whole-metagenome sequence data generated by the IBD Multi'omics Database project. By associating phages with their hosts via genome comparisons, we found that temperate bacteriophages infect a phylogenetically wide range of bacteria. The majority of variance in bacteriophage community composition was explaiMicroorganismsEcological Structuring of Temperate Bacteriophages in the Inflammatory Bowel Disease-Affected Gut.PMC769295616H0642916H06437U54 DK10255719J1422816K21723Blanc-Mathieu ROgata HNishiyama HEndo HfalseEcological Structuring of Temperate Bacteriophages in the Inflammatory Bowel Disease-Affected Gut.The aim of this study was to elucidate the ecological structure of the human gut temperate bacteriophage community and its role in inflammatory bowel disease (IBD). Temperate bacteriophages make up a large proportion of the human gut microbiota and are likely to play a role in IBD pathogenesis. However, many of these bacteriophages await characterization in reference databases. Therefore, we conducted a large-scale reconstruction of temperate bacteriophage and bacterial genomes from the whole-metagenome sequence data generated by the IBD Multi'omics Database project. By associating phages with their hosts via genome comparisons, we found that temperate bacteriophages infect a phylogenetically wide range of bacteria. The majority of variance in bacteriophage community composition was explai2020-01-01T00:00:00Z2020 Oct2026-04-08T00:35:40.622Z2021-02-20T00:55:43ZS-EPMC76929563312100610.3390/microorganisms8111663