biostudies-literatureBarik SKIndian Council of Medical Research, Govt. of India898https://www.ebi.ac.uk/biostudies/studies/S-EPMC7694411biostudies-literatureUnknown20(1)<h4>Background</h4>Plasma proteins are known to interfere the drug metabolism during therapy. As limited information is available regarding the role of plasma proteins in HIV drug resistance during ART in HIV/AIDS patients, the present study aimed to identify and characterize the differentially expressed plasma proteins in the drug resistant and drug respondent groups of HIV-1 infected patients with > 6 years of first line ART.<h4>Methods</h4>Four-drug resistant (treatment failure) and four-drug respondent (treatment responder) patients were selected for plasma proteomic analysis based on viral load and drug resistance associated mutations from a cohort study designed on the first line ART patients who were enrolled in the antiretroviral therapy center, Sarojini Naidu Medical College, AgraBMC infectious diseasesIdentification and differential expression of serotransferrin and apolipoprotein A-I in the plasma of HIV-1 patients treated with first-line antiretroviral therapy.PMC769441180/990/2015-ECD-I.Mohanty KKSingh TPGopal GTripathy SPBarik SKJena SPatil SABisht DRawat PSharma DMohanty AKSingh RTandon RfalseIdentification and differential expression of serotransferrin and apolipoprotein A-I in the plasma of HIV-1 patients treated with first-line antiretroviral therapy.<h4>Background</h4>Plasma proteins are known to interfere the drug metabolism during therapy. As limited information is available regarding the role of plasma proteins in HIV drug resistance during ART in HIV/AIDS patients, the present study aimed to identify and characterize the differentially expressed plasma proteins in the drug resistant and drug respondent groups of HIV-1 infected patients with > 6 years of first line ART.<h4>Methods</h4>Four-drug resistant (treatment failure) and four-drug respondent (treatment responder) patients were selected for plasma proteomic analysis based on viral load and drug resistance associated mutations from a cohort study designed on the first line ART patients who were enrolled in the antiretroviral therapy center, Sarojini Naidu Medical College, Agra2020-01-01T00:00:00Z2020 Nov2026-05-01T00:59:30.87Z2021-02-20T03:04:36ZS-EPMC76944113324644010.1186/s12879-020-05610-6