{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Panya A"],"funding":["undefined  &lt;span style=&quot;color:gray;font-size:10px;&quot;&gt;undefined&lt;/span&gt;"],"pagination":["E1267"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7694746"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(11)"],"pubmed_abstract":["Dengue virus (DENV) infection has become a critically important globally prevalent infectious disease, especially in tropical and subtropical countries. Since neither currently exists, there is an urgent need for an effective vaccine to prevent, and a specific drug to treat DENV infection. Therapeutic peptides represent an attractive alternative for development into anti-DENV drugs due to their safety and their diverse biological and chemical properties. We recently reported novel bioactive peptides extracted from the Asian medicinal plant <i>Acacia catechu</i> that efficiently inhibited all four DENV serotypes. In this study, we investigated the anti-DENV activity of a synthetic bioactive peptide derived from this plant. The most effective peptide (designated Pep-RTYM) inhibited DENV infe"],"journal":["Viruses"],"pubmed_title":["A Synthetic Bioactive Peptide Derived from the Asian Medicinal Plant <i>Acacia catechu</i> Binds to Dengue Virus and Inhibits Cell Entry."],"pmcid":["PMC7694746"],"funding_grant_id":["xx"],"pubmed_authors":["Choowongkomon K","Sawasdee N","Rotarayanont S","Panya A","Yenchitsomanus PT","Songprakhon P","Tragoolpua Y"],"additional_accession":[]},"is_claimable":false,"name":"A Synthetic Bioactive Peptide Derived from the Asian Medicinal Plant <i>Acacia catechu</i> Binds to Dengue Virus and Inhibits Cell Entry.","description":"Dengue virus (DENV) infection has become a critically important globally prevalent infectious disease, especially in tropical and subtropical countries. Since neither currently exists, there is an urgent need for an effective vaccine to prevent, and a specific drug to treat DENV infection. Therapeutic peptides represent an attractive alternative for development into anti-DENV drugs due to their safety and their diverse biological and chemical properties. We recently reported novel bioactive peptides extracted from the Asian medicinal plant <i>Acacia catechu</i> that efficiently inhibited all four DENV serotypes. In this study, we investigated the anti-DENV activity of a synthetic bioactive peptide derived from this plant. The most effective peptide (designated Pep-RTYM) inhibited DENV infe","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Nov","modification":"2026-05-04T04:17:43.368Z","creation":"2021-02-20T00:55:47Z"},"accession":"S-EPMC7694746","cross_references":{"pubmed":["33172110"],"doi":["10.3390/v12111267"]}}