biostudies-literaturePanya Aundefined &lt;span style=&quot;color:gray;font-size:10px;&quot;&gt;undefined&lt;/span&gt;E1267https://www.ebi.ac.uk/biostudies/studies/S-EPMC7694746biostudies-literatureUnknown12(11)Dengue virus (DENV) infection has become a critically important globally prevalent infectious disease, especially in tropical and subtropical countries. Since neither currently exists, there is an urgent need for an effective vaccine to prevent, and a specific drug to treat DENV infection. Therapeutic peptides represent an attractive alternative for development into anti-DENV drugs due to their safety and their diverse biological and chemical properties. We recently reported novel bioactive peptides extracted from the Asian medicinal plant <i>Acacia catechu</i> that efficiently inhibited all four DENV serotypes. In this study, we investigated the anti-DENV activity of a synthetic bioactive peptide derived from this plant. The most effective peptide (designated Pep-RTYM) inhibited DENV infeVirusesA Synthetic Bioactive Peptide Derived from the Asian Medicinal Plant <i>Acacia catechu</i> Binds to Dengue Virus and Inhibits Cell Entry.PMC7694746xxChoowongkomon KSawasdee NRotarayanont SPanya AYenchitsomanus PTSongprakhon PTragoolpua YfalseA Synthetic Bioactive Peptide Derived from the Asian Medicinal Plant <i>Acacia catechu</i> Binds to Dengue Virus and Inhibits Cell Entry.Dengue virus (DENV) infection has become a critically important globally prevalent infectious disease, especially in tropical and subtropical countries. Since neither currently exists, there is an urgent need for an effective vaccine to prevent, and a specific drug to treat DENV infection. Therapeutic peptides represent an attractive alternative for development into anti-DENV drugs due to their safety and their diverse biological and chemical properties. We recently reported novel bioactive peptides extracted from the Asian medicinal plant <i>Acacia catechu</i> that efficiently inhibited all four DENV serotypes. In this study, we investigated the anti-DENV activity of a synthetic bioactive peptide derived from this plant. The most effective peptide (designated Pep-RTYM) inhibited DENV infe2020-01-01T00:00:00Z2020 Nov2026-05-04T04:17:43.368Z2021-02-20T00:55:47ZS-EPMC76947463317211010.3390/v12111267