biostudies-literatureUnknown9(11)Alciati AAbout half of the patients with fibromyalgia (FM) had a lifetime major depression episode and one third had a panic disorder (PD). Because the co-morbidity between bipolar disorder (BD) and PD marks a specific subtype of BD we aimed to investigate if co-morbid BD/PD (comBD/PD) occurs more frequently than the single disorder in FM patients and evaluate the clinical significance and timing of this co-morbidity. Further, we explored the role of co-morbid subthreshold BD and PD. In 118 patients with FM, lifetime threshold and sub-threshold mood disorders and PD were diagnosed with Diagnostic and Statistical Manual of Mental Disorders-IV-Text Revision (DSM-IV-TR) Clinical Interview. Demographic and clinical variables were compared in co-morbid BD/PD (comBD/PD) and not co-morbid BD/PD (nocomBD/PJournal of clinical medicineE3619https://www.ebi.ac.uk/biostudies/studies/S-EPMC7697979biostudies-literatureThe Co-Morbidity between Bipolar and Panic Disorder in Fibromyalgia Syndrome.PMC7697979Caldirola DPerna GAlciati ASarzi-Puttini PAtzeni FfalseThe Co-Morbidity between Bipolar and Panic Disorder in Fibromyalgia Syndrome.About half of the patients with fibromyalgia (FM) had a lifetime major depression episode and one third had a panic disorder (PD). Because the co-morbidity between bipolar disorder (BD) and PD marks a specific subtype of BD we aimed to investigate if co-morbid BD/PD (comBD/PD) occurs more frequently than the single disorder in FM patients and evaluate the clinical significance and timing of this co-morbidity. Further, we explored the role of co-morbid subthreshold BD and PD. In 118 patients with FM, lifetime threshold and sub-threshold mood disorders and PD were diagnosed with Diagnostic and Statistical Manual of Mental Disorders-IV-Text Revision (DSM-IV-TR) Clinical Interview. Demographic and clinical variables were compared in co-morbid BD/PD (comBD/PD) and not co-morbid BD/PD (nocomBD/P2020-01-01T00:00:00Z2020 Nov2025-06-01T03:51:48.178Z2025-06-01T03:51:48.178ZS-EPMC76979793318275910.3390/jcm9113619