{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["9(11)"],"submitter":["Gao D"],"pubmed_abstract":["Currently, many extracts from natural sources are added to cosmetic products for reducing facial aging and wrinkles. This study investigated the antiwrinkle activity of enriched extract of Isatidis Folium used for a novel antiwrinkle cream product. The result demonstrated that this enriched extract has excellent antiwrinkle activity by significantly inhibiting mRNA expression of matrix metalloproteinase-1, matrix metalloproteinase-3, and pro-inflammatory cytokines IL-1β and upregulating the mRNA expression of IL-4 and procollagen. Additionally, to implement effective quality control of the entire manufacturing process of antiwrinkle cream products based on the enriched extract of Isatidis Folium, the main chemical constituents of the enriched extract of Isatidis Folium was evaluated by hig"],"journal":["Plants (Basel, Switzerland)"],"pagination":["E1586"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7698272"],"repository":["biostudies-literature"],"pubmed_title":["Evaluation of the Antiwrinkle Activity of Enriched Isatidis Folium Extract and an HPLC-UV Method for the Quality Control of Its Cream Products."],"pmcid":["PMC7698272"],"pubmed_authors":["Kim CT","Cho CW","Jeong WS","Kang JS","Gao D"],"additional_accession":[]},"is_claimable":false,"name":"Evaluation of the Antiwrinkle Activity of Enriched Isatidis Folium Extract and an HPLC-UV Method for the Quality Control of Its Cream Products.","description":"Currently, many extracts from natural sources are added to cosmetic products for reducing facial aging and wrinkles. This study investigated the antiwrinkle activity of enriched extract of Isatidis Folium used for a novel antiwrinkle cream product. The result demonstrated that this enriched extract has excellent antiwrinkle activity by significantly inhibiting mRNA expression of matrix metalloproteinase-1, matrix metalloproteinase-3, and pro-inflammatory cytokines IL-1β and upregulating the mRNA expression of IL-4 and procollagen. Additionally, to implement effective quality control of the entire manufacturing process of antiwrinkle cream products based on the enriched extract of Isatidis Folium, the main chemical constituents of the enriched extract of Isatidis Folium was evaluated by hig","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Nov","modification":"2025-06-01T03:51:37.541Z","creation":"2025-06-01T03:51:37.541Z"},"accession":"S-EPMC7698272","cross_references":{"pubmed":["33207681"],"doi":["10.3390/plants9111586"]}}