{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["9(11)"],"submitter":["Wicik Z"],"pubmed_abstract":["Background
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection (coronavirus disease 2019; COVID-19) is associated with adverse outcomes in patients with cardiovascular disease (CVD). The aim of the study was to characterize the interaction between SARS-CoV-2 and Angiotensin-Converting Enzyme 2 (ACE2) functional networks with a focus on CVD.Methods
Using the network medicine approach and publicly available datasets, we investigated ACE2 tissue expression and described ACE2 interaction networks that could be affected by SARS-CoV-2 infection in the heart, lungs and nervous system. We compared them with changes in ACE-2 networks following SARS-CoV-2 infection by analyzing public data of human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs). T"],"journal":["Journal of clinical medicine"],"pagination":["E3743"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7700637"],"repository":["biostudies-literature"],"pubmed_title":["ACE2 Interaction Networks in COVID-19: A Physiological Framework for Prediction of Outcome in Patients with Cardiovascular Risk Factors."],"pmcid":["PMC7700637"],"pubmed_authors":["Pavao R","Postula M","Wicik Z","Jakubik D","Simoes SN","Siller-Matula JM","Martins DC","Eyileten C"],"additional_accession":[]},"is_claimable":false,"name":"ACE2 Interaction Networks in COVID-19: A Physiological Framework for Prediction of Outcome in Patients with Cardiovascular Risk Factors.","description":"Background
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection (coronavirus disease 2019; COVID-19) is associated with adverse outcomes in patients with cardiovascular disease (CVD). The aim of the study was to characterize the interaction between SARS-CoV-2 and Angiotensin-Converting Enzyme 2 (ACE2) functional networks with a focus on CVD.Methods
Using the network medicine approach and publicly available datasets, we investigated ACE2 tissue expression and described ACE2 interaction networks that could be affected by SARS-CoV-2 infection in the heart, lungs and nervous system. We compared them with changes in ACE-2 networks following SARS-CoV-2 infection by analyzing public data of human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs). T","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Nov","modification":"2026-07-10T03:10:32.19Z","creation":"2021-02-20T02:55:00Z"},"accession":"S-EPMC7700637","cross_references":{"pubmed":["33233425"],"doi":["10.3390/jcm9113743"]}}