{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Hsu IU"],"funding":["HHS | NIH | National Institute of Arthritis and Musculoskeletal and Skin Diseases","HHS | NIH | National Institute of Neurological Disorders and Stroke","NINDS NIH HHS","NIAMS NIH HHS","NIGMS NIH HHS"],"pagination":["29914-29924"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7703553"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["117(47)"],"pubmed_abstract":["Neuropeptides are important for regulating numerous neural functions and behaviors. Release of neuropeptides requires long-lasting, high levels of cytosolic Ca<sup>2+</sup> However, the molecular regulation of neuropeptide release remains to be clarified. Recently, Stac3 was identified as a key regulator of L-type Ca<sup>2+</sup> channels (CaChs) and excitation-contraction coupling in vertebrate skeletal muscles. There is a small family of <i>stac</i> genes in vertebrates with other members expressed by subsets of neurons in the central nervous system. The function of neural Stac proteins, however, is poorly understood. <i>Drosophila melanogaster</i> contain a single <i>stac</i> gene, <i>Dstac</i>, which is expressed by muscles and a subset of neurons, including neuropeptide-expressing mot"],"journal":["Proceedings of the National Academy of Sciences of the United States of America"],"pubmed_title":["Stac protein regulates release of neuropeptides."],"pmcid":["PMC7703553"],"funding_grant_id":["RO1 NS032385","RO1 NS069844","R01 NS069844","R01 NS032385","T32 GM007315","R01 AR063056"],"pubmed_authors":["Lum MC","Leflein A","Hume RI","Hsu IU","Reid LE","Collins CA","Xu H","Linsley JW","Kuwada JY","Zhang X","Levitan ES","Berkhoudt DA","Orzel AM","Varineau JE"],"additional_accession":[]},"is_claimable":false,"name":"Stac protein regulates release of neuropeptides.","description":"Neuropeptides are important for regulating numerous neural functions and behaviors. Release of neuropeptides requires long-lasting, high levels of cytosolic Ca<sup>2+</sup> However, the molecular regulation of neuropeptide release remains to be clarified. Recently, Stac3 was identified as a key regulator of L-type Ca<sup>2+</sup> channels (CaChs) and excitation-contraction coupling in vertebrate skeletal muscles. There is a small family of <i>stac</i> genes in vertebrates with other members expressed by subsets of neurons in the central nervous system. The function of neural Stac proteins, however, is poorly understood. <i>Drosophila melanogaster</i> contain a single <i>stac</i> gene, <i>Dstac</i>, which is expressed by muscles and a subset of neurons, including neuropeptide-expressing mot","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Nov","modification":"2025-04-18T16:50:16.8Z","creation":"2022-02-10T09:17:47.803Z"},"accession":"S-EPMC7703553","cross_references":{"pubmed":["33168737"],"doi":["10.1073/pnas.2009224117"]}}