{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Nuckols VR"],"funding":["NICHD NIH HHS","NIEHS NIH HHS","NHLBI NIH HHS"],"pagination":["1800-1807"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC7706825"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["76(6)"],"pubmed_abstract":["Women with preeclampsia, a hypertensive disorder of pregnancy, exhibit greater beat-to-beat blood pressure variability (BPV) in the third trimester after clinical onset of the disorder. However, it remains unknown whether elevated BPV precedes the development of preeclampsia. A prospective study cohort of 139 women (age 30.2±4.0 years) were enrolled in early pregnancy (<14 weeks gestation). BPV was quantified by time domain analyses of 10-minute continuous beat-to-beat blood pressure recordings via finger photoplethysmography in the first, second, and third trimesters. Aortic stiffness (carotid-femoral pulse wave velocity) and spontaneous cardiovagal baroreflex sensitivity were also measured each trimester. Eighteen women (13%) developed preeclampsia. Systolic BPV was higher in all trimest"],"journal":["Hypertension (Dallas, Tex. : 1979)"],"pubmed_title":["Beat-to-Beat Blood Pressure Variability in the First Trimester Is Associated With the Development of Preeclampsia in a Prospective Cohort: Relation With Aortic Stiffness."],"pmcid":["PMC7706825"],"funding_grant_id":["R01 HD089940","R01 HL134850","P30 ES005605","P01 HL084207","R35 HL144807","L30 HD070302"],"pubmed_authors":["Pierce GL","Luehrs RE","Brandt D","Holwerda SW","Fiedorowicz JG","Betz AM","Grobe JL","Scroggins SM","Nuckols VR","DuBose LE","Sigmund CD","Santillan DA","Stroud AK","Santillan MK"],"additional_accession":[]},"is_claimable":false,"name":"Beat-to-Beat Blood Pressure Variability in the First Trimester Is Associated With the Development of Preeclampsia in a Prospective Cohort: Relation With Aortic Stiffness.","description":"Women with preeclampsia, a hypertensive disorder of pregnancy, exhibit greater beat-to-beat blood pressure variability (BPV) in the third trimester after clinical onset of the disorder. However, it remains unknown whether elevated BPV precedes the development of preeclampsia. A prospective study cohort of 139 women (age 30.2±4.0 years) were enrolled in early pregnancy (<14 weeks gestation). BPV was quantified by time domain analyses of 10-minute continuous beat-to-beat blood pressure recordings via finger photoplethysmography in the first, second, and third trimesters. Aortic stiffness (carotid-femoral pulse wave velocity) and spontaneous cardiovagal baroreflex sensitivity were also measured each trimester. Eighteen women (13%) developed preeclampsia. Systolic BPV was higher in all trimest","dates":{"release":"2020-01-01T00:00:00Z","publication":"2020 Dec","modification":"2026-05-08T18:23:45.989Z","creation":"2022-02-11T13:14:44.682Z"},"accession":"S-EPMC7706825","cross_references":{"pubmed":["32951467"],"doi":["10.1161/hypertensionaha.120.15019","10.1161/HYPERTENSIONAHA.120.15019"]}}