biostudies-literatureNuckols VRNICHD NIH HHSNIEHS NIH HHSNHLBI NIH HHS1800-1807https://www.ebi.ac.uk/biostudies/studies/S-EPMC7706825biostudies-literatureUnknown76(6)Women with preeclampsia, a hypertensive disorder of pregnancy, exhibit greater beat-to-beat blood pressure variability (BPV) in the third trimester after clinical onset of the disorder. However, it remains unknown whether elevated BPV precedes the development of preeclampsia. A prospective study cohort of 139 women (age 30.2±4.0 years) were enrolled in early pregnancy (<14 weeks gestation). BPV was quantified by time domain analyses of 10-minute continuous beat-to-beat blood pressure recordings via finger photoplethysmography in the first, second, and third trimesters. Aortic stiffness (carotid-femoral pulse wave velocity) and spontaneous cardiovagal baroreflex sensitivity were also measured each trimester. Eighteen women (13%) developed preeclampsia. Systolic BPV was higher in all trimestHypertension (Dallas, Tex. : 1979)Beat-to-Beat Blood Pressure Variability in the First Trimester Is Associated With the Development of Preeclampsia in a Prospective Cohort: Relation With Aortic Stiffness.PMC7706825R01 HD089940R01 HL134850P30 ES005605P01 HL084207R35 HL144807L30 HD070302Pierce GLLuehrs REBrandt DHolwerda SWFiedorowicz JGBetz AMGrobe JLScroggins SMNuckols VRDuBose LESigmund CDSantillan DAStroud AKSantillan MKfalseBeat-to-Beat Blood Pressure Variability in the First Trimester Is Associated With the Development of Preeclampsia in a Prospective Cohort: Relation With Aortic Stiffness.Women with preeclampsia, a hypertensive disorder of pregnancy, exhibit greater beat-to-beat blood pressure variability (BPV) in the third trimester after clinical onset of the disorder. However, it remains unknown whether elevated BPV precedes the development of preeclampsia. A prospective study cohort of 139 women (age 30.2±4.0 years) were enrolled in early pregnancy (<14 weeks gestation). BPV was quantified by time domain analyses of 10-minute continuous beat-to-beat blood pressure recordings via finger photoplethysmography in the first, second, and third trimesters. Aortic stiffness (carotid-femoral pulse wave velocity) and spontaneous cardiovagal baroreflex sensitivity were also measured each trimester. Eighteen women (13%) developed preeclampsia. Systolic BPV was higher in all trimest2020-01-01T00:00:00Z2020 Dec2026-05-08T18:23:45.989Z2022-02-11T13:14:44.682ZS-EPMC77068253295146710.1161/hypertensionaha.120.1501910.1161/HYPERTENSIONAHA.120.15019